At the Department of Toxicogenomics (TGX), a multidisciplinary team of biologists, chemists, toxicologists and bioinformaticians is working in close collaboration to establish the biological impact of exposures to potentially toxic compounds. The rapid development of the new, so called omics-technologies, has enabled us to establish responses at different molecular levels with higher sensitivity than most classical effect markers, and providing information on the involved molecular mechanisms of action. As such, toxicogenomics research combines toxicology with genomics approaches in order to obtain more accurate understanding of toxicological processes. The application of these innovative omics-technologies in in vitro toxicology and human health risk analysis can be regarded as the central research paradigm of our department.
The mission of Department of Toxicogenomics is to explore, develop and to exploit the full potential of innovative cell technologies and genomics platforms, for the purpose of advancing mechanism-based in vitro assays using human cells, for predictive toxicology, as well as for developing novel biomarkers of toxic exposure and effect to be used in human population studies.
The department has strong collaborations both at the national level within the context of the Netherlands Toxicogenomics Centre, which is coordinated from our department, and at the international level in the context of numerous EU and non-EU projects. Within Maastricht University there is a long history of collaboration with various clinical departments in the Maastricht University Medical Centre (MUMC+). The Department of Toxicogenomics is part of the GROW Research School for Oncology and Developmental Biology.