Department of Toxicogenomics


  1. Albrecht, C, Knaapen, AM, Becker, A, Hoehr, D, Haberzettl, P, Schooten, FJ van, Borm, P.J., & Schins, RP (2005). The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen/nitrogen species formation and APE/Ref-1 induction in rat lung. Respir Res, 6(1), 129.
  2. Barjesteh van Waalwijk van Doorn-Khosrovani S, Spensberger D, de Knegt Y, Tang M, Lowenberg B, Delwel R.Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia. Oncogene. 2005 Jun 9;24(25):4129-37.
  3. Borm, P.J., Cakmak, G, Jermann, E, Weishaupt, C, Kempers, P, Schooten, FJ van, Oberdorster, G, & Schins, RP (2005). Formation of PAH-DNA adducts after in vivo and vitro exposure of rats and lung cells to different commercial carbon blacks. Toxicol Appl Pharmacol, 205(2), 157-167.
  4. Breda, SG van, Agen, E van, Sanden, S van, Burzykowski, T, Kienhuis, AS, Kleinjans, JC, & Delft, JH van (2005). Vegetables affect the expression of genes involved in anticarcinogenic processes in the colonic mucosa of C57BL/6 female mice. Journal of Nutrition, 135(8), 1879-1888.
  5. Breda, SG van, Agen, E van, Sanden, S van, Burzykowski, T, Kleinjans, JC, & Delft, JH van (2005). Vegetables affect the expression of genes involved in carcinogenic and anticarcinogenic processes in the lungs of female C57BL/6 mice. Journal of Nutrition, 135(11), 2546-2552.
  6. Breikers G, van Breda SGJ, Bouwman FG, van Herwijnen MHM, Renes JW, Mariman ECM, Kleinjans JCS, van Delft JHM Identification of proteins differentially expressed in the colon of C57BL6 mice by altered vegetable intake. Proteomics In Press.
  7. Briedé JJ, Pot RGJ, Kuipers EJ, van Vliet AHM, Kleinjans JCS, Kusters JG. The presence of the Cag-pathogenicity Island is associated with increased ROS scavenging by H. pylori. FEMS Immunology & Medical Microbiology 44 (2005) 227-232 (IF 1.8)
  8. Briedé, J.J., de Kok, T.M.C.M., Hogervorst, J.G.F., Moonen, E.J.C. Moonen, op den Kamp, C.L.V., Kleinjans, J.C.S. (2005) Development and application of an Electron Spin Resonance Spectrometry method for the determination of oxygen free radial formation by particulate matter. Env Sci Technol. 39, 8420-8426.
  9. Corvi R, Ahr H, Albertini S, Blakey DH, Clerici L, Coecke S, Douglas GR, Gribaldo L, Groten JP, Haase B, Hamernik K, Hartung T, Inoue T, Indans I, Maurici D, Orphanides G, Rembges D, Sansone S, Snape JR, Toda E, Tong W, Delft JH, Weis B, and Schechtman LM. 2005. Validation of Toxicogenomics-Based Test Systems: ECVAM-ICCVAM/NICEATM Considerations for Regulatory Use Environ Health Perspect: doi:10.1289/ehp.8247. [Online 17 August 2005]
  10. Cramers, P, Atanasova, P, Vrolijk, H, Darroudi, F, Zeeland, AA van, Huiskamp, R, Mullenders, LH, & Kleinjans, JC (2005). Pre-exposure to Low Doses: Modulation of X-Ray-Induced DNA Damage and Repair? Radiation Research, 164(4), 383-390.
  11. Curfs, DMJ, Knaapen, AM, Pachen, DMFA, Gijbels, MJ, Lutgens, E, Smook, ML, Kockx, MM, Daemen, MJ, & Schooten, FJ van (2005). Polycyclic aromatic hydrocarbons induce an inflammatory atherosclerotic plaque phenotype irrespective of their DNA binding properties. Faseb Journal, 19, 1290-1292.
  12. Godschalk, R, Hogervorst, J, Albering, H, Roumans, P Mercelina, Schooten, FJ van, Haan, J de, & Kleinjans, J (2005). Interaction between cadmium and aromatic DNA adducts in hprt mutagenesis during foetal development. Mutagenesis, 20(3), 181-185.
  13. Heijne WHM, Kienhuis AS, van Ommen B, Stierum RH, Groten JP; “Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology”; Expert Review Proteomics 2(5), 767-780 (2005) Published
  14. Knaapen, AM, Schins, RP, Borm, P.J., & Schooten, FJ van (2005). Nitrite enhances neutrophil-induced DNA strand breakage in pulmonary epithelial cells by inhibition of myeloperoxidase. Carcinogenesis, 26, 1642-1648.
  15. Kok, TMCM de, Engels, L, Moonen, EJC, & Kleinjans, JCS (2005). Endogenous formation of carcinogenic N-nitroso compounds in the colon of patients with chronic inflammatory bowel disease. Gut, 54, 731-732.
  16. Kok, TMCM de, Hogervorst, JGF, Briede, JJ, Herwijnen, MHM van, Maas, LM, Moonen, EJC, Driece, HA, Camp, CL op den, & Kleinjans, JCS (2005). Genotoxicity and physicochemical characteristics of traffic-related ambient particulate matter. Environmental and Molecular Mutagenesis, 46, 71-80.
  17. Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH. Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11 Blood. 2005 Apr 1;105(7):2900-7. Epub 2004 Dec 7.
  18. Larebeke, NA Van, Birnbaum, LS, Boogaerts, MA, Bracke, M, Davis, DL, Demarini, DM, Hooper, K, Huff, J, Kleinjans, JC, Legator, MS, Schoeters, G, & Vahakangas, K (2005). Unrecognized or potential risk factors for childhood cancer. Int J Occup Environ Health, 11(2), 199-201.
  19. Lee, Y, Hao, W, Nordling, MM, Kok, TMCM de, Low, C, & Rafter, JJ (2005). Human fecal water modifies adhesion of intestinal bacteria to caco-2 cells. Nutrition and Cancer-An International Journal, 52, 35-42.
  20. Leeuwen, DM van, Gottschalk, R.W., Herwijnen, MHM van, Moonen, EJC, Kleinjans, JC, & Delft, JH van (2005). Differential gene expression in human peripheral blood mononuclear cells induced by cigarette smoke and its constituents. Toxicological Sciences, 86(1), 200-210
  21. Mercken E.M., Hageman G.J. Schols A.M.W.J., Bast A., Wouters E.F.M. (2005) Exercise-induced oxidative stress in COPD before and after rehabilitation, Am. J. Resp. Crit. Care Med., 172, 994-1001.
  22. Moonen, H, Engels, L, Kleinjans, J, & Kok, T de (2005). The CYP1A2-164A-->C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans. Cancer Letters, 229(1), 25-31.
  23. Moonen, HJ, Geraets, L, Vaarhorst, A., Bast, A, Wouters, EF, & Hageman, GJ (2005). Theophylline prevents NAD(+) depletion via PARP-1 inhibition in human pulmonary epithelial cells. Biochem Biophys Res Commun, 338(4), 1805-1810.
  24. Sarrif, A, Delft, JH van, Gant, TW, Kleinjans, JC, & Vliet, E van (2005). Toxicogenomics in genetic toxicology and hazard determination--concluding remarks. Mutation Research, 575(1-2), 116-117.
  25. Sarrif A, Van Delft JHM, Gant TW, Elliott B, Van Ravenzwaay B, Van Schooten FJ, Van Steeg H, Vrijhof H. Toxicogenomics in Genetic Toxicology and Hazard Determination – Introduction and Overview. Mutation Res  575 :1-3, 2005
  26. Staal, Y, Herwijnen, MHM van, Schooten, FJ van, & Delft, JH van (2005). Application of four dyes in gene expression analyses by microarrays. BMC Genomics, 6, 101. Staal, YC, Herwijnen, MH van, Schooten, FJ van, & Delft, JH van (2005). Modulation of gene expression and DNA adduct formation in HepG2 cells by polycyclic aromatic hydrocarbons with different carcinogenic potencies. Carcinogenesis.
  27. Steerenberg, PA, Withagen, CE, Dalen, WJ, Dormans, JA, Heisterkamp, SH, Loveren, H van, & Cassee, FR (2005). Dose dependency of adjuvant activity of particulate matter from five European sites in three seasons in an ovalbumin-mouse model. Inhalation Toxicology, 17(3), 133-145.
  28. Stierum RH, Heijne WHM, Kienhuis AS, van Ommen B, Groten JP; “Toxicogenomics concepts and applications to study hepatic effects of food additives and chemicals”; Toxicology and Applied Pharmacology 207 (2005) S179-S188 Published
  29. van Delft JHM, van Benthem J. Introduction to the special issue on genes and environment—bridging the gap. Mutation Res, 2005;574(1-2):1-2
  30. Delft JHM van, Agen, E van, Breda, SG van, Herwijnen, MHM van, Staal, Y, & Kleinjans, JC (2005). Comparison of supervised clustering methods to discriminate genotoxic from non-genotoxic carcinogens by gene expression profiling. Mutation Research, 575(1-2), 17-33.
  31. van den Berg FA, Baken KA, Vermeulen JP, Gremmer ER, van Steeg H, van Loveren H. Use of the local lymph node assay in assessment of immune function. Toxicology. 2005 Jul 1;211(1-2):107-14. Epub 2005 Apr 7.
  32. Van Och FMM, Van Loveren H, Van Wolfswinkel JC, Machielsen AJC, Vandebriel RJ. Assessement of allergenic activity of low molecular weight compounds base don IL-1á and IL-18 production by a murine keratinocyte cell line. Toxicol 2005, 210, 95-109.
  33. Vos, JG, Van der Laan, JW, Van Loveren, H, Albers, R, Pieters, R; Immunotoxicology. Mechanisms of immunotoxicity by pharmaceuticals, 2005, 559-589
  34. Ward, M., de Kok, T.M., Levallois, P., Brender, J., Gulis, G, Nolan, B.T., VanDerslice, J. (2005) Drinking Water Nitrate and Health –Recent Findings and Research Needs. Env. Health Persp. 2005 113, 1607-1614.
  35. Wijk, SJ van, & Hageman, GJ (2005). Poly(ADP-ribose) polymerase-1 mediated caspase-independent cell death after ischemia/reperfusion. Free Radic Biol Med, 39(1), 81-90.
  36. Wilms, LC, Hollman, PC, Boots, AW, & Kleinjans, JC (2005). Protection by quercetin and quercetin-rich fruit juice against induction of oxidative DNA damage and formation of BPDE-DNA adducts in human lymphocytes. Mutation Research, 582(1-2), 155-162.


Nationaal gerefereerde tijdschr.

Barjesteh van Waalwijk van Doorn-Khosrovani S, Lowenberg B, Delwel R. The prognosis triangle. Ned tijd Hematologie 2005

Nationaal boek

Van Schooten FJ, Godschalk RWL. De Gezondheidsrisico’s van Passief roken. In “Tabaksgebruik: gevolgen en bestrijding” Eds: Knol K, Hilvering C, Wagener Th, Willemsen M. Uitgever LEMMA, Utrecht, pp 23-246, 2004.

Letter to the editor intern

  1. Kok, TM de, Engels, LG, Moonen, EJ, & Kleinjans, JC (2005). Inflammatory bowel disease stimulates formation of carcinogenic N-nitroso compounds. Gut, 54(5), 731.


  1. Zhai R. Genotypic and phenotypic factors contributing to the development and progression of pneumoconiosis


  1. Passchier WF, Lebret E, Midden CHJ, Seinen W. Gezondheidseffectscreening Moerdijkse Hoek. Derde advies van de Wetenschappelijke Toetsingscommissie Gezondheid-effectscreening Moerdijkse Hoek [Health effect screening Moerdijkse Hoek. Third report of the scientific advisory committee]. 's-Hertogenbosch: Provicie Noord-Brabant; 5-3-2005.
  2. Passchier WF, Lebret E, Midden CHJ, Seinen W. Gezondheidseffectscreening Moerdijkse Hoek. Vierde advies van de Wetenschappelijke Toetsingscommissie Gezondheid-effectscreening Moerdijkse Hoek [Health effect screening Moerdijkse Hoek. Fourth report of the scientific advisory committee]. 's-Hertogenbosch: Provicie Noord-Brabant; 31-7-2005.