Department of Toxicogenomics


  1. Baken KA, Pennings JLA, Breit TM, de Vries A, van Steeg H, van Loveren H. Gene expression profiling of bis(tri-n-butyltin)oxide (TBTO) induced immunotoxicity in mice and rats.. Journal of Immunotoxicology 2006;3(4): 227-244.
  2. Becker A, Alrbrecht C, Knaapen AM, Schins RP, Hohr D, Ledermann K, Borm PJ. Induction of CYP1A1 in ratlung cells following in vivo and in vitro exposure to quartz. Arch Toxicol 2006 May; 80(5): 258-68.
  3. Breikers G, van Breda SG, Bouwman FG, van Herwijnen MH, Renes J, Mariman EC, Kleinjans JCS, van Delft JH; Potential protein markers for nutritional health effects on colorectal cancer in the mouse as revealed by proteomics analysis. Proteomics 2006 May; 6(9): 2844-52.
  4. Clare MG, Lorenzon G, Akhurst LC, Marzin D, van Delft JH, Montero R, Botta A, Bertens A, Cinelli S, Thybaud V and Lorge E SFTG. International collaborative study on in vitro micronucleus test II. Using human lymphocytes. Mutat-Res 2006; 607(1): 37-60.
  5. Corvi R, Ahr H, Albertini S, Blakey DH, Clerici L, Coecke S, Douglas GR, Gribaldo L, Groten JP, Haase B, Hamernik K, Hartung T, Inoue T, Indans I, Maurici D, Orphanides G, Rembges D, Sansone S, Snape JR, Toda E, Tong W, Delft JH, Weis B, and Schechtman LM. 2005. Validation of Toxicogenomics-Based Test Systems: ECVAM-ICCVAM/NICEATM Considerations for Regulatory Use. Environ. Health Perspect, 2006;114(3):420-9.
  6. Ezendam J, van Loveren H. Probiotics: immunomodulation and evaluation of safety and efficacy. Nutr Rev. 2006 Jan;64(1):1-14. Review.
  7. Geraets L, Moonen HJ, Wouters EF, Bast A, Hageman GJ. Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations. Biochem Pharmacol 2006 Sept 28; 72(7): 902-10.
  8. Hamers T, van den Berg JH, van Gestel CA, van Schooten FJ, Murk AJ. Risk assessment of metals and organic pollutants for herbivorous and carnivorous small mammal food chains in a polluted floodplain (Bieschbosch, The Netherlands). Environ Polut 2006 Nov; 144(2): 581-95.
  9. Hendriksen PJM, Dits NFJ, Veldhoven A, van Weerden WM, Bangma CH, Trapman J, Jenster G. Evolution of the androgen receptor pathway during progression of prostate cancer. Cancer Research 2006. 66:5012-5020.
  10. Hogervorst JG, de Kok TM, Briede JJ, Wesseling G, Kleinjans JCS, van Schayck CP. Relationship between radical generation by urban ambient particulate matter and pulmonary function of school children. J Toxicol Environ Health A. 2006 Feb; 69(3-4): 245-62.
  11. Ketelslegers HB, Gottschalk RW, Godschalk RW, Knaapen AM, van Schooten FJ, Vlietinck RF, Kleinjans JC, van Delft JH. Interindividual variations in DNA adduct levels assessed by analysis of multiple genetic polymorphisms in smokers. Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):624-9.
  12. Kienhuis AS, Wortelboer HM, Hoflack JC, Moonen EJ, Kleinjans JCS, van Ommen B, van Delft JH, Stierum RH; Comparison of coumarin-induced toxicity between sandwich-cultured primary rat hepatocytes and rats in vivo: a toxicogenomics approach.
  13. Knaapen AM, Gungor N, Schins RP, Borm PJ, Van Schooten FJ. Neutrophils and respiratory tract DNA damage and mutagenesis: a review. Mutagenesis. 2006 Jul; 21(4): 225-36
  14. Langie S.A.S., Knaapen A.M., Brauers K.J.J., Van Schooten FJ, Godschalk R.W.L. A modified Comet Assay to phenotypically assess inter-individual variations in nucleotide excision repair. Mutagenesis vol. 21 no. 2 pp. 153–158, 2006
  15. Langie SA, Knaapen AM, Brauers KJ, van Berlo D, van Schooten FJ, Godschalk RW.Development and validation of a modified comet assay to phenotypically assess nucleotide excision repair. Mutagenesis. 2006 Mar;21(2):153-8.
  16. Langie SA, Knaapen AM, Houben JM, van Kempen FC, de Hoon JP, Gottschalk RW, Godschalk RW, van Schooten FJ. The role of glutathione in the regulation of nucleotide excision repair during oxidative stress. Toxicol Lett. 2006.
  17. Pedersen M, Vinzents P, Petersen JH, Kleinjans JC, Plas G, Kirsch-Volders M, Dostal M, Rossner P, Beskid O, Sram RJ, Merlo DF, Knudsen LE. Cytogenetic effects in children and mothers exposed to air pollution assessed by the frequency of micronuclei and fluorescence in situ hybridization (FISH): a family pilot study in the Czech Republic. Mutation Research-Genetic Toxicology and Environmental Mutagenesis 2006, 608(2), 112-120.
  18. Sarrif A, Kyrtopoulos SA, Autrup H, Farmer P, Kirsch-Volders M, Kleinjans JC, Knudsen LE, Mathar U, Wiegand HJ, Vrijhof H. Environmental genotoxins in children and adults: introduction and overview. Mutat Res. 2006 Sep 28;608(2):97-9. Epub 2006 Jul 11. Letter to the Editor
  19. Staal YC, van Herwijnen MH, Pushparajah DS, Umachandran M, Ioannides C, van Schooten FJ, van Delft JH. Modulation of gene expression and DNA-adduct formation in precision-cut liver slices exposed to polycyclic aromatic hydrocarbons of different carcinogenic potency. Mutagenesis. 2007 Jan;22(1):55-62.
  20. Staal YC, van Herwijnen MH, van Schooten FJ, van Delft JH. Modulation of gene expression and DNA adduct formation in HepG2 cells by polycyclic aromatic hydrocarbons with different carcinogenic potencies. Carcinogenesis. 2006 Mar;27(3):646-55. Epub 2005 Nov 3.
  21. Steerenberg PA, Daamen F, Weesendorp E, Van Loveren H. No adaptation to UV-induced immunosuppression and DNA damage following exposure of mice to chronic UV-exposure. J Photochem Photobiol B. 2006 Jul 3;84(1):28-37. Epub 2006 Feb 28.
  22. van der Heul-Nieuwenhuijsen L, Hendriksen PJM, van der Kwast TH, Jenster G. (2006). Gene expression profiling of the human prostate zones. BJU Int 98:886-97.
  23. van Leeuwen DM, van Herwijnen MH, Pedersen M, Knudsen LE, Kirsch-Volders M, Sram RJ, Staal YC, Bajak E, van Delft JH, Kleinjans JC. Genome-wide differential gene expression in children exposed to air pollution in the Czech Republic. Mutat Res. 2006 Aug 30;600(1-2):12-22.
  24. van Leeuwen DM, van Agen E, Gottschalk RW, Vlietinck R, Gielen M, van Herwijnen MH, Maas LM, Kleinjans JC, van Delft JH. Cigarette smoke-induced differential gene expression in blood cells from monozygotic twin pairs. Carcinogenesis. 2006 Oct 19.
  25. Veraldi A, Costantini AS, Bolejack V, Miligi L, Vineis P, van Loveren H. Immunotoxic effects of chemicals: A matrix for occupational and environmental epidemiological studies. Am J Ind Med. 2006 Dec;49(12):1046-55.
  26. van Schayck CP, Hogervorst JG, de Kok TM, Briede JJ, Wesseling G, Kleinjans JCS. Relationship between the composition of fine dust particles in the air and lung function in school children Ned Tijdschr Geneeskd. 2006 Apr 1;150(13):735-40.
  27. Zeegers MP, Selen RF, Kleinjans JC, Goldbohm RA, van den Brandt PA. Nitrate intake does not influence bladder cancer risk: the Netherlands cohort study. Environ Health Perspect. 2006 Oct;114(10):1527-31.


  1. Leeuwen, D.M. van (2006, december 07). Applicability of toxicogenomics in molecular epidemiology; Gene expression profiling as a new biomarker. UM Universiteit Maastricht (155 pag.) (Maastricht: Datawyse Boekproducties). Promotor/copromotor.: J Kleinjans and J van Delft