Department of Toxicogenomics


  1. van Dartel DA, Pennings JL, Robinson JF, Kleinjans JC, Piersma AH. Discriminating classes of developmental toxicants using gene expression profiling in the embryonic stem cell test. Toxicol Lett. 2011 Mar 5;201(2):143-51. Epub 2010 Dec 30. PubMed PMID: 21195148.
  2. van Dartel DA, Pennings JL, de la Fonteyne LJ, Brauers KJ, Claessen S, van Delft JH, Kleinjans JC, Piersma AH. Concentration-dependent gene expression responses to flusilazole in embryonic stem cell differentiation cultures. Toxicol Appl Pharmacol. 2011 Mar 1;251(2):110-8. Epub 2010 Dec 28. PubMed PMID: 21192963.
  3. Van Summeren A, Renes J, Bouwman FG, Noben JP, van Delft JH, Kleinjans JC, Mariman EC. Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22. Epub 2010 Dec 16. PubMed PMID: 21163907.
  4. Paules RS, Aubrecht J, Corvi R, Garthoff B, Kleinjans JC. Moving forward in human cancer risk assessment. Environ Health Perspect. 2011 Jun;119 (6):739-43. Epub 2010 Dec 13. PubMed PMID: 21147607; PubMed Central PMCID: PMC3114805.
  5. Stølevik SB, Nygaard UC, Namork E, Granum B, Pellerud A, van Leeuwen DM, Gmuender H, van Delft JH, van Loveren H, Løvik M. In vitro cytokine release from human peripheral blood mononuclear cells in the assessment of the immunotoxic potential of chemicals. Toxicol In Vitro. 2011 Mar;25(2):555-62. Epub 2010 Dec 7. PubMed PMID: 21144890.
  6. van Kol SW, Hendriksen PJ, van Loveren H, Peijnenburg A. The effects of deoxynivalenol on gene expression in the murine thymus. Toxicol Appl Pharmacol. 2011 Feb 1;250(3):299-311. Epub 2010 Nov 11. PubMed PMID: 21074547.
  7. Kienhuis AS, Bessems JG, Pennings JL, Driessen M, Luijten M, van Delft JH, Peijnenburg AA, van der Ven LT. Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study. Toxicol Appl Pharmacol. 2011 Jan 15;250(2):96-107. Epub 2010 Oct 21. Review. PubMed PMID: 20970440.
  8. Burley VJ, Greenwood DC, Hepworth SJ, Fraser LK, de Kok TM, van Breda SG, Kyrtopoulos SA, Botsivali M, Kleinjans J, McKinney PA, Cade JE. Dietary acrylamide intake and risk of breast cancer in the UK women's cohort. Br J Cancer. 2010 Nov 23;103(11):1749-54. Epub 2010 Oct 19. PubMed PMID: 20959829; PubMed Central PMCID: PMC2994225.
  9. van Dartel DA, Pennings JL, de la Fonteyne LJ, Brauers KJ, Claessen S, van Delft JH, Kleinjans JC, Piersma AH. Evaluation of developmental toxicant identification using gene expression profiling in embryonic stem cell differentiation cultures. Toxicol Sci. 2011 Jan;119(1):126-34. Epub 2010 Oct 8. PubMed PMID: 20935163.
  10. van Grinsven HJ, Rabl A, de Kok TM. Estimation of incidence and social cost of colon cancer due to nitrate in drinking water in the EU: a tentative cost-benefit assessment. Environ Health. 2010 Oct 6;9:58. PubMed PMID: 20925911; PubMed Central PMCID: PMC2973935.
  11. Jennen DG, Gaj S, Giesbertz PJ, van Delft JH, Evelo CT, Kleinjans JC. Biotransformation pathway maps in WikiPathways enable direct visualization of drug metabolism related expression changes. Drug Discov Today. 2010 Oct;15(19-20):851-8. Epub 2010 Aug 11. Review. PubMed PMID: 20708095.
  12. Hochstenbach K, van Leeuwen DM, Gmuender H, Stølevik SB, Nygaard UC, Løvik M, Granum B, Namork E, van Delft JH, van Loveren H. Transcriptomic profile indicative of immunotoxic exposure: in vitro studies in peripheral blood mononuclear cells. Toxicol Sci. 2010 Nov;118(1):19-30. Epub 2010 Aug 11. PubMed PMID: 20702593.
  13. Osman AM, Pennings JL, Blokland M, Peijnenburg A, van Loveren H. Protein expression profiling of mouse thymoma cells upon exposure to the trichothecene deoxynivalenol (DON): implications for its mechanism of action. J Immunotoxicol. 2010 Jul-Sep;7(3):147-56. PubMed PMID: 20672443.
  14. Tonk EC, de Groot DM, Penninks AH, Waalkens-Berendsen ID, Wolterbeek AP, Slob W, Piersma AH, van Loveren H. Developmental immunotoxicity of methylmercury: the relative sensitivity of developmental and immune parameters. Toxicol Sci. 2010 Oct;117(2):325-35. Epub 2010 Jul 21. PubMed PMID: 20660081.
  15. Mathijs K, Brauers KJ, Jennen DG, Lizarraga D, Kleinjans JC, van Delft JH. Gene expression profiling in primary mouse hepatocytes discriminates true from false-positive genotoxic compounds. Mutagenesis. 2010 Nov;25(6):561-8. Epub 2010 Jul 21. PubMed PMID: 20650930.
  16. van Delft JH, Mathijs K, Staal YC, van Herwijnen MH, Brauers KJ, Boorsma A, Kleinjans JC. Time series analysis of benzo[A]pyrene-induced transcriptome changes suggests that a network of transcription factors regulates the effects on functional gene sets. Toxicol Sci. 2010 Oct;117(2):381-92. Epub 2010 Jul 12. PubMed PMID: 20624995.
  17. Vandebriel RJ, Pennings JL, Baken KA, Pronk TE, Boorsma A, Gottschalk R, Van Loveren H. Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9. Epub 2010 Jun 20. PubMed PMID: 20566472.
  18. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining. J Cheminform. 2010 Jun 3;2(1):4. PubMed PMID: 20525267; PubMed Central PMCID: PMC2890529.
  19. van Dartel DA, Pennings JL, de la Fonteyne LJ, van Herwijnen MH, van Delft JH, van Schooten FJ, Piersma AH. Monitoring developmental toxicity in the embryonic stem cell test using differential gene expression of differentiation-related genes. Toxicol Sci. 2010 Jul;116(1):130-9. Epub 2010 Apr 26. PubMed PMID: 20421339.
  20. Verhagen H, Vos E, Francl S, Heinonen M, van Loveren H. Status of nutrition and health claims in Europe. Arch Biochem Biophys. 2010 Sep 1;501(1):6-15. Epub 2010 Apr 22. Review. PubMed PMID: 20417175.
  21. Hebels DG, Briedé JJ, Khampang R, Kleinjans JC, de Kok TM. Radical mechanisms in nitrosamine- and nitrosamide-induced whole-genome gene expression modulations in Caco-2 cells. Toxicol Sci. 2010 Jul;116(1):194-205. Epub 2010 Apr 19. PubMed PMID: 20403970.
  22. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining. J Cheminform. 2010 Mar 23;2(1):3. PubMed PMID: 20331846; PubMed Central PMCID: PMC2848622.
  23. Eussen S, Klungel O, Garssen J, Verhagen H, van Kranen H, van Loveren H, Rompelberg C. Support of drug therapy using functional foods and dietary supplements: focus on statin therapy. Br J Nutr. 2010 May;103(9):1260-77. Epub 2010 Mar 3. PubMed PMID: 20196891.
  24. Pedersen M, Halldorsson TI, Mathiesen L, Mose T, Brouwer A, Hedegaard M, Loft S, Kleinjans JC, Besselink H, Knudsen LE. Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs. Environ Int. 2010 May;36(4):344-51. Epub 2010 Feb 26. PubMed PMID: 20189248.
  25. Vandebriel RJ, van Loveren H. Non-animal sensitization testing: state-of-the-art. Crit Rev Toxicol. 2010 May;40(5):389-404. Review. PubMed PMID: 20180632.
  26. Le TV, Rumbak MJ, Liu SS, Alsina AE, van Loveren H, Agazzi S. Insertion of intracranial pressure monitors in fulminant hepatic failure patients: early experience using recombinant factor VII. Neurosurgery. 2010 Mar;66(3):455-8; discussion 458. PubMed PMID: 20173540.
  27. Jennen DG, Magkoufopoulou C, Ketelslegers HB, van Herwijnen MH, Kleinjans JC, van Delft JH. Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79. Epub 2010 Jan 27. PubMed PMID: 20106945.
  28. Briedé JJ, van Delft JM, de Kok TM, van Herwijnen MH, Maas LM, Gottschalk RW, Kleinjans JC. Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. Epub 2009 Dec 31. PubMed PMID: 20044591.
  29. de Kok TM, de Waard P, Wilms LC, van Breda SG. Antioxidative and antigenotoxic properties of vegetables and dietary phytochemicals: the value of genomics biomarkers in molecular epidemiology. Mol Nutr Food Res. 2010 Feb;54(2):208-17. Review. PubMed PMID: 20024933.
  30. Lankveld DP, Van Loveren H, Baken KA, Vandebriel RJ. In vitro testing for direct immunotoxicity: state of the art. Methods Mol Biol. 2010;598: 401-23. PubMed PMID: 19967527.
  31. Langie SA, Wilms LC, Hämäläinen S, Kleinjans JC, Godschalk RW, van Schooten FJ. Modulation of nucleotide excision repair in human lymphocytes by genetic and dietary factors. Br J Nutr. 2010 Feb;103(4): 490-501. Epub 2009 Nov 2. PubMed PMID: 19878615.