Department of Toxicogenomics

2008

  1. Amelsvoort van LGPM, Mohren D, Slangen J, Swaen G, Corsini E, Fustinoni S, Vergieva T, Bosetti C, Liesivuori J, Tarkowski M, Colosio C & Van Loveren H. Immune effects and exposure to ethylene bisdithiocarba mate pesticides in re-entry workers in The Netherlands. Human & Experimental Toxicology (2008) 27(9), 693-9
  2. Arbillaga L, Vettorazzi A, Gil AG, van Delft JH, García-Jalón JA, López de Cerain A. Gene expression changes induced by ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration. Toxicol Appl Pharmacol. 2008 Jul 15;230(2):197-207. Epub 2008 Mar 4. PMID: 18417182
  3. Arts JH, de Jong WH, van Triel JJ, Schijf MA, de Klerk A, van Loveren H, Kuper CF. The respiratory local lymph node assay as a tool to study respiratory sensitizers. Toxicol Sci. 2008 Dec;106(2):423-34. Epub 2008 Sep 23.
  4. Baken KA, Pennings JL, Jonker MJ, Schaap MM, de Vries A, van Steeg H, Breit TM, van Loveren H. Overlapping gene expression profiles of model compounds provide opportunities for immunotoxicity screening. Toxicol Appl Pharmacol. 2008 Jan 1;226(1):46-59. Epub 2007 Sep 12.
  5. Baranska M, Van Amelsvoort L, Birindelli S, Fustinoni S, Corsini E, Liesivuori J, Van Loveren H. Association of pesticide exposure, vaccination response, and interleukin-1 gene polymorphisms. Hum Exp Toxicol. 2008 Sep;27(9):709-13. PMID: 19042953
  6. Barjesteh van Waalwijk van Doorn-Khosrovani S, Vanhees K, Ruijters E, van Schooten FJ. Etoposide-initiated MLL rearrangements: the pitfalls of inverse PCR. Eur J Haematol. 2008 Dec;81(6):486-8. No abstract available. PMID: 18774953
  7. Basketter D, Cockshott A, Corsini E, Gerberick GF, Idehara K, Kimber I, Van Loveren H, Matheson J, Mehlin A, Omori T, Rovida C, Sozu T, Takeyoshi M & Casati S. An evaluation of performance standards and non-radioactive endpoints for the local lymph node assay. The report and recommendations of ECVAM Workshop 65. ATLA-Alternatives to laboratory animals. 2008 36(2), 243-57
  8. Boers D, van Amelsvoort L, Colosio C, Corsini E, Fustinoni S, Campo L, Bosetti C, La Vecchia C, Vergieva T, Tarkowski M, Liesivuori J, Steerenberg P, van Loveren H. Asthmatic symptoms after exposure to ethylenebisdithiocarbamates and other pesticides in the Europit field studies. Hum Exp Toxicol. 2008 Sep;27(9):721-7. PMID: 19042955
  9. Boots AW, Wilms LC, Swennen EL, Kleinjans JC, Bast A, Haenen GR. In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers. Nutrition. 2008 Jul-Aug;24(7-8):703-10. PMID: 18549926
  10. Brun J, Chiu R, Lockhart K, Xiao W, Wouters BG, Gray DA. hMMS2 serves a redundant role in human PCNA polyubiquitination. BMC Mol Biol. 2008 Feb 19;9:24
  11. Corsini E, Liesivuori J, Vergieva T, Van Loveren H, Colosio C. Effects of pesticide exposure on the human immune system. Hum Exp Toxicol. 2008 Sep;27(9):671-80. PMID: 19042949
  12. De Jonge PJ, Siersema PD, Van Breda SG, Van Zoest KP, Bac DJ, Leeuwenburgh I, Ouwendijk RJ, Van Dekken H, Kusters JG, Kuipers EJ. Proton pump inhibitor therapy in gastro-oesophageal reflux disease decreases the oesophageal immune response but does not reduce the formation of DNA adducts. Aliment Pharmacol Ther. 2008 Jul;28(1):127-36. Epub 2008 Mar 31.
  13. De Kok TM, van Breda SG, Manson MM. Mechanisms of combined action of different chemopreventive dietary compounds: a review. Eur J Nutr. 2008 May;47 Suppl 2:51-9. Review. PMID: 18458834
  14. De Waard WJ, Aarts JM, Peijnenburg AA, Baykus H, Talsma E, Punt A, De Kok TM, Van Schooten FJ & Hoogenboom LA. Gene expression profiling in Caco-2 human colon cells exposed to TCDD, benzo[a]pyrene, and natural Ah receptor agonists from cruciferous vegetables and citrus fruits. Toxicology in Vitro 2008. 22(2): 396-410
  15. De Waard PW, de Kok TM, Maas LM, Peijnenburg AA, Hoogenboom RL, Aarts JM, van Schooten FJ. Influence of TCDD and natural Ah receptor agonists on benzo[a]pyrene-DNA adduct formation in the Caco-2 human colon cell line. Mutagenesis. 2008 Jan;23(1):67-73. Epub 2007 Dec 7. PMID: 18065724
  16. De Waard WJ, Aarts JM, Peijnenburg AC, De Kok TM, Van Schooten FJ, Hoogenboom LA. Ah receptor agonist activity in frequently consumed food items. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jun;25(6):779-87. PMID: 18484306
  17. De Waard PW, Peijnenburg AA, Baykus H, Aarts JM, Hoogenboom RL, van Schooten FJ, de Kok TM. A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine. Chem Biol Interact. 2008 Oct 22;176(1):19-29. Epub 2008 Aug 13. PMID: 18762178
  18. Ellinger-Ziegelbauer H, Aubrecht J, Kleinjans JC, Ahr HJ. Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity. Toxicol Lett. 2008 Sep 4. PMID: 18822359
  19. Ezendam J, de Klerk A, Gremmer ER, van Loveren H. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008 Dec;154(3):424-31. PMID: 19037925  
  20. Ezendam J & Van Loveren H. Lactobacillus casei Shirota administered during lacatation increases the duration of autoimmunity in rats and enhances lung inflammation in mice. British Journal of Nutrition 2008. 99(1), 83-90
  21. Fustinoni S, Campo L, Liesivuori J, Pennanen S, Vergieva T, van Amelsvoort L, Bosetti C, Van Loveren H, Colosio C. Biological monitoring and questionnaire for assessing exposure to ethylenebisdithiocarbamates in a multicenter European field study. Hum Exp Toxicol. 2008 Sep;27(9):681-91. PMID: 19042950
  22. Godschalk RW, Kleinjans JC. Characterization of the exposure-disease continuum in neonates of mothers exposed to carcinogens during pregnancy. Basic Clin Pharmacol Toxicol. 2008 Feb;102(2):109-17. Review. PMID: 18226063
  23. Hoeks J, Briedé JJ, de Vogel J, Schaart G, Nabben M, Moonen-Kornips E, Hesselink MK, Schrauwen P. Mitochondrial function, content and ROS production in rat skeletal muscle: effect of high-fat feeding. FEBS Lett. 2008 Feb 20;582(4):510-6. Epub 2008 Jan 28. PMID: 18230360
  24. Houben JM, Mercken EM, Ketelslegers HB, Bast A, Wouters EF, Hageman GJ, Schols AM. Telomere shortening in chronic obstructive pulmonary disease. Respir Med. 2008 Oct 20. PMID: 18945604
  25. Houben JM, Moonen HJ, van Schooten FJ, Hageman GJ. Telomere length assessment: biomarker of chronic oxidative stress? Free Radic Biol Med. 2008 Feb 1; 44(3):235-46. Epub 2007 Oct 10. Review. PMID: 18021748
  26. Jonas E, Schreinemachers HJ, Kleinwächter T, Un C, Oltmanns I, Tetzlaff S, Jennen D, Tesfaye D, Ponsuksili S, Murani E, Juengst H, Tholen E, Schellander K, Wimmers K. QTL for the heritable inverted teat defect in pigs. Mamm Genome. 2008 Feb;19(2):127-38. Epub 2008 Jan 25. PMID: 18219525 [PubMed - in process]
  27. Jong de NA, Plat J, Bast A, Godschalk RW, Basu S & Mensink RP. Effects of plant sterol and stanol ester consumption on lipid metabolism, antioxidant status and markers of oxidative stress, endothelial function and low-grade inflammation in patients on current statin treatment European Journal of Clinical Nutrition 2008. 62(2), 263-273
  28. Ketelslegers HB, Gottschalk RW, Koppen G, Schoeters G, Baeyens WF, van Larebeke NA, van Delft JH, Kleinjans JC. Multiplex genotyping as a biomarker for susceptibility to carcinogenic exposure in the FLEHS biomonitoring study. Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):1902-12. PMID: 18708379
  29. Kienhuis AS, van de Poll MC, Wortelboer H, van Herwijnen M, Gottschalk R, Dejong CH, Boorsma A, Paules RS, Kleinjans JC, Stierum RH, van Delft JH. Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans. Toxicol Sci. 2008 Nov 12.
  30. Li H, van Berlo D, Shi T, Speit G, Knaapen AM, Borm PJ, Albrecht C, Schins RP. Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line. Toxicol Appl Pharmacol. 2008 Feb 15;227(1):115-24. Epub 2007 Oct 11. PMID: 18001810
  31. Lizárraga D, Touriño S, Reyes-Zurita FJ, de Kok TM, van Delft JH, Maas LM, Briedé JJ, Centelles JJ, Torres JL, Cascante M. Witch hazel (Hamamelis virginiana) fractions and the importance of gallate moieties--electron transfer capacities in their antitumoral properties. J Agric Food Chem. 2008 Dec 24;56(24):11675-82.PMID: 19035659
  32. Moons LM, Kusters JG, van Delft JH, Kuipers EJ, Gottschalk R, Geldof H, Bode WA, Stoof J, van Vliet AH, Ketelslegers HB, Kleinjans JC, Siersema PD. A pro-inflammatory genotype predisposes to Barrett's esophagus. Carcinogenesis. 2008 May;29(5):926-31. Epub 2008 Jan 12. PMID: 18192685
  33. Moretti S, van Leeuwen D, Gmuender H, Bonassi S, van Delft J, Kleinjans J, Patrone F, Merlo DF. Combining Shapley value and statistics to the analysis of gene expression data in children exposed to air pollution.BMC Bioinformatics. 2008 Sep 2;9:361. PMID: 18764936
  34. Nabben M, Hoeks J, Briedé JJ, Glatz JF, Moonen-Kornips E, Hesselink MK, Schrauwen P. The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice. FEBS Lett. 2008 Dec 24;582(30):4147-52. Epub 2008 Nov 27. PMID: 19041310
  35. Powlson DS, Addiscott TM, Benjamin N, Cassman KG, de Kok TM, van Grinsven H, L'Hirondel JL, Avery AA, van Kessel C. When does nitrate become a risk for humans? J Environ Qual. 2008 Feb 11;37(2):291-5. Print 2008 Mar-Apr. Review. PMID: 18268290
  36. Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ. Implications of gene-drug interactions in smoking cessation for improving the prevention of chronic degenerative diseases. Mutat Res. 2008 Nov 5. [PMID: 19028511
  37. Rijnkels JM, Smid T, Van den Aker EC, Burdorf A, van Wijk RG, Heederik DJ, Houben GF, Van Loveren H, Pal TM, Van Rooy FG, Van der Zee JS; Health Council of the Netherlands. Prevention of work-related airway allergies; summary of the advice from the Health Council of the Netherlands. Allergy. 2008 Dec;63(12):1593-6.PMID: 19032231
  38. Schroijen C, Baeyens W, Schoeters G, Den Hond E, Koppen G, Bruckers L, Nelen V, Van De Mieroop E, Bilau M, Covaci A, Keune H, Loots I, Kleinjans J, Dhooge W, Van Larebeke N. Internal exposure to pollutants measured in blood and urine of Flemish adolescents in function of area of residence. Chemosphere. 2008 Apr;71(7):1317-25. Epub 2008 Jan 24. PMID: 18221770
  39. Staal YC, Pushparajah DS, van Herwijnen MH, Gottschalk RW, Maas LM, Ioannides C, van Schooten FJ, van Delft JH. Interactions between polycyclic aromatic hydrocarbons in binary mixtures: effects on gene expression and DNA adduct formation in precision-cut rat liver slices. Mutagenesis. 2008 Nov;23(6):491-9. Epub 2008 Aug 18.PMID: 18711122
  40. Steerenberg P, van Amelsvoort L, Colosio C, Corsini E, Fustinoni S, Vergieva T, Zaikov C, Pennanen S, Liesivuori J, Van Loveren H. Toxicological evaluation of the immune function of pesticide workers, a European wide assessment. Hum Exp Toxicol. 2008 Sep;27(9):701-7. PMID: 19042952
  41. Swaen G, van Amelsvoort L, Boers D, Corsini E, Fustinoni S, Vergieva T, Bosetti C, Pennanen S, Liesivuori J, Colosio C, van Loveren H. Occupational exposure to ethylenebisdithiocarbamates in agriculture and allergy: results from the EUROPIT field study. Hum Exp Toxicol. 2008 Sep;27(9):715-20. PMID: 19042954
  42. Van Berkel JJBN, Dallinga JW, Moller GM, Godschalk RW, Moonen E, Wouters EF & Schooten FJ van; Development of accurate classification method based on the analysis of volatile organic compounds from human exhaled air. Journal of Chromatography B-analytical Technologies in the Biomedical and L, 861(1), 101-107
  43. Van Breda SG, De Kok T, Van Delft JH. Mechanisms of colorectal and lung cancer prevention by vegetables: a genomic approach. Journal of Nutritional Biochemistry 2008, 19(3), 139-157 PMID: 17651960
  44. Van Helden YG, Keijer J, Knaapen AM, Heil SG, Briedé JJ, van Schooten FJ, Godschalk RW. beta-Carotene metabolites enhance inflammation-induced oxidative DNA damage in lung epithelial cells. Free Radic Biol Med. 2009 Jan 15;46(2):299-304. Epub 2008 Oct 31.PMID: 19026740
  45. Van Leeuwen DM, Gottschalk RW, Schoeters G, van Larebeke NA, Nelen V, Baeyens WF, Kleinjans JC, van Delft JH. Transcriptome analysis in peripheral blood of humans exposed to environmental carcinogens: a promising new biomarker in environmental health studies. Environ Health Perspect. 2008 Nov;116(11):1519-25. Epub 2008 Jun 23. PMID: 19057705
  46. Van Leeuwen DM, Pedersen M, Hendriksen PJ, Boorsma A, van Herwijnen MH, Gottschalk RW, Kirsch-Volders M, Knudsen LE, Srám RJ, Bajak E, van Delft JH, Kleinjans JC. Genomic analysis suggests higher susceptibility of children to air pollution. Carcinogenesis. 2008 May;29(5):977-83. Epub 2008 Mar 10. PMID: 18332047
  47. Van Loveren H. Toxicological evaluation of the immune function of pesticide workers, a European wide assessment. Hum Exp Toxicol. 2008 Sep;27(9):669. No abstract available. PMID: 19042948
  48. Verhofstad N, Linschooten JO, van Benthem J, Dubrova YE, van Steeg H, van Schooten FJ, Godschalk RW. New methods for assessing male germ line mutations in humans and genetic risks in their offspring.Mutagenesis. 2008 Jul;23(4):241-7. Epub 2008 May 20. Review. PMID: 18495641
  49. Vinken M, Doktorova T, Ellinger-Ziegelbauer H, Ahr HJ, Lock E, Carmichael P, Roggen E, van Delft J, Kleinjans J, Castell J, Bort R, Donato T, Ryan M, Corvi R, Keun H, Ebbels T, Athersuch T, Sansone SA, Rocca-Serra P, Stierum R, Jennings P, Pfaller W, Gmuender H, Vanhaecke T, Rogiers V. The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays. Mutat Res. 2008 Sep-Oct;659(3):202-10. Epub 2008 Apr 26. Review. PMID: 18514569
  50. Visschers VH, Meertens RM, Passchier WW, de Vries NN. Probability Information in Risk Communication: A Review of the Research Literature. Risk Anal. 2009 Feb;29(2):267-87. Epub 2008 Nov 5.
  51. Visschers VHM, Meertens RM, Passchier WF, de Vries NK. Audiovisual risk communication unravelled: effects on gut feelings and cognitive processes. J Risk Res. 2008;11(1-2):207-21.
  52. Weijenberg MP, Aardening PW, de Kok TM, de Goeij AF, van den Brandt PA. Cigarette smoking and KRAS oncogene mutations in sporadic colorectal cancer: results from the Netherlands Cohort Study. Mutat Res. 2008 Mar 29;652(1):54-64. Epub 2008 Jan 11. PMID: 18296105
  53. Wilms LC, Kleinjans JC, Moonen EJ, Briedé JJ. Discriminative protection against hydroxyl and superoxide anion radicals by quercetin in human leucocytes in vitro. Toxicol In Vitro. 2008 Mar;22(2):301-7. Epub 2007 Sep 14. PMID: 17959353
  54. Wimmers K, Ngu NT, Jennen DG, Tesfaye D, Murani E, Schellander K, Ponsuksili S. Relationship between myosin heavy chain isoform expression and muscling in several diverse pig breeds. J Anim Sci. 2008 Apr;86(4):795-803. Epub 2007 Dec 21. PMID: 18156349
  55. Yauk C, Polyzos A, Rowan-Carroll A, Somers CM, Godschalk RW, Van Schooten FJ, Berndt ML, Pogribny IP, Koturbash I, Williams A, Douglas GR, Kovalchuk O. Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):605-10. Epub 2008 Jan 14. PMID: 18195365

 

Ahead of print

  1. Boots AW, Drent M, Swennen EL, Moonen HJ, Bast A & Haenen GR. Antioxidant status associated with inflammation in sarcoidosis: A potential role for antioxidants. Respir Med. 2008 Nov 14. [Epub ahead of print]
  2. Simone G. J. van Breda, Joost H. M. van Delft, Leopold G. J. B. Engels, Jos C. S. Kleinjans and John C. Mathers; Methylation status of CpG islands in the promoter region of genes differentially expressed in colonic mucosa from adenoma patients and controls in response to altered vegetable intake 2008. British Journal of Nutrition

Abstracts

Hettne KM, Verhallen DAM, Stierum RH, Hendriksen PJM, Schijvenaars BJA, Kleinjans J, Kors JA. The added value of text mining in toxicogenomics experimental setup. In: Abstracts of the Netherlands Society of Toxicology PhD Students Meeting held in Wageningen, The Netherlands 17–18 June 2008. Mutagenesis vol. 23 no. supplement 1 pp. i1–i13, 2008.

Bookchapters

  1. State of the art of genotype vs. phenotype studies. Hirvonen A, Godschalk R, Kirsch-Volders M, Van Schooten F; 2008 ECNIS
  2. Wouters EFM , Wagers S and Dallinga JW. Biomarkers in Chronic Obstructive Pulmonary Disease. 2008. In: Biomarkers in Chronic Obstructive Lung Diseases 2, Ch.24, pp 357-367. N.F Voelkel and W. MacNee (editors), B.C.Decker Inc. Hamilton, Ontario.
  3. Wouters BG and Chiu RK. Evaluating the importance of apoptosis and other determinants of cell death and survival. In Dewritz, D.A., Holt, S.E. and Grant, S. (Eds) Cancer drug discovery and development: Apoptosis, senescence and cancer. Totawa, NJ: Humana Press  

Books

Barjesteh van Waalwijk van Doorn- Khosrovani S, Barjesteh van Waalwijk van Doorn LAF, Van Gestel T, Plooij FX. Zonen van Adam in Nederland: een zoektocht in ons DNA-archief, Gronsveld 2008. ISBN 97890 5613 9407

Reports

Passchier WF, Erisman JW, van den Hazel PJ, Heederik D, Leemans R, Legler J, van der Sluijs JP, Dogger JW, van Vliet PW. Waterstof in het wegverkeer [Hydrogen-powered road vehicles]. Den Haag: Gezondheidsraad; 2008 september 29. Publicatie nr 2008/16. Internet: http://www.gezondheidsraad.nl/referentie.php?ID=1753, accessed 03-11-2008

Theses

  1. Anne Susan Kienhuis. Prediction of Hepatoxic Responses in Humans. A Toxicogenomics-based parallelogram approach. 2008. Promotor J Kleinjans, Co-promotores J van Delft & R Stierum
  2. Sabine AS Langie. Nutritional Modulation of DNA repair. 2008. Promotor FJ van Schooten, co-promtor R Godschalk
  3. Pim de Waard. Natural Ah receptor agonists in the human diet: beneficial food components or unperceived risk factors? 2008. Promotor FJ van Schooten, Co-promotores T de Kok & J Aarts
  4. A Vos. Preclinical studies on the immune-modulatory effects of dietary oligosaccharides. Promotores H van Loveren & J Garssen