Department of Toxicogenomics

2009

  1. Albrecht C, Scherbart AM, van Berlo D, Braunbarth CM, Schins RP, Scheel J. Evaluation of cytotoxic effects and oxidative stress with hydroxyapatite dispersions of different physicochemical properties in rat NR8383 cells and primary macrophages. Toxicol In Vitro. 2009 Apr;23(3):520-30
  2. De Jong WH, Arts JH, De Klerk A, Schijf MA, Ezendam J, Kuper CF, Van Loveren H. Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure. Toxicology. 2009 Jul 10;261(3):103-11.
  3. Gerlofs-Nijland ME, Rummelhard M, Boere AJ, Leseman DL, Duffin R, Schins RP, Borm PJ, Sillanpää M, Salonen RO, Cassee FR. Particle induced toxicity in relation to transition metal and polycyclic aromatic hydrocarbon contents. Environ Sci Technol. 2009 Jul 1;43(13):4729-36.
  4. Güngör N, Godschalk RW, Pachen DM, Van Schooten FJ, Knaapen AM. Activated neutrophils inhibit nucleotide excision repair in human pulmonary epithelial cells: role of myeloperoxidase. FASEB J. 2007 Aug;21(10):2359-67.
  5. Hebels DG, Jennen DG, Kleinjans JC, de Kok TM. Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis. Toxicol Sci. 2009 Apr;108(2):290-300
  6. Hettne KM, Stierum RH, Schuemie MJ, Hendriksen PJ, Schijvenaars BJ, van Mulligen EM, Kleinjans J, Kors JA. A Dictionary to Identify Small Molecules and Drugs in Free Text. Bioinformatics. 2009 Sep 16. [Epub ahead of print]
  7. Hockley SL, Mathijs K, Staal YC, Brewer D, Giddings I, van Delft JH, Phillips DH. Interlaboratory and Interplatform Comparison of Microarray Gene Expression Analysis of HepG2 Cells Exposed to Benzo(a)pyrene. OMICS. 2009 Apr;13(2):115-25.
  8. Ketelslegers HB, Godschalk RW, Eskens BJ, Dallinga JW, Gottschalk RW, van Schooten FJ, van Delft JH, Kleinjans JC. Potential role of cytochrome P450-1B1 in the metabolic activation of 4-aminobiphenyl in humans. Mol Carcinog. 2009 Aug;48(8):685-91
  9. Kienhuis AS, van de Poll MC, Wortelboer H, van Herwijnen M, Gottschalk R, Dejong CH, Boorsma A, Paules RS, Kleinjans JC, Stierum RH, van Delft JH. Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans. Toxicol Sci. 2009 Feb;107(2):544-52.
  10. Kienhuis AS, van de Poll MC, Dejong CH, Gottschalk R, van Herwijnen M, Boorsma A, Kleinjans JC, Stierum RH, van Delft JH A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo. Toxicol In Vitro. 2009 Sep;23(6):1163-9.
  11. Linschooten JO, Van Schooten FJ, Baumgartner A, Cemeli E, Van Delft J, Anderson D, Godschalk RW. Use of spermatozoal mRNA profiles to study gene-environment interactions in human germ cells. Mutat Res. 2009 Jul 10;667(1-2):70-6
  12. Mathijs K, Kienhuis AS, Brauers KJ, Jennen DG, Lahoz A, Kleinjans JC, van Delft JH. Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes. Drug Metab Dispos. 2009 Jun;37(6):1305-11. Epub 2009 Feb 27.
  13. Merlo DF, Wild CP, Kogevinas M, Kyrtopoulos S, Kleinjans J; NewGeneris Consortium. NewGeneris: a European study on maternal diet during pregnancy and child health. Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):5-10.
  14. Osman AM, van Kol S, Peijnenburg A, Blokland M, Pennings JL, Kleinjans JC, van Loveren H. Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO). J Immunotoxicol. 2009 Sep;6(3):174-83
  15. Park MV, Lankveld DP, van Loveren H, de Jong WH. The status of in vitro toxicity studies in the risk assessment of nanomaterials. Nanomed. 2009 Aug;4(6):669-85.
  16. Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ. Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases? Eur Respir J. 2009 Mar;33(3):468-80.
  17. Theys J, Jutten B, Dubois L, Rouschop KM, Chiu RK, Li Y, Paesmans K, Lambin P, Lammering G, Wouters BG. The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment. Radiother Oncol. 2009 Sep;92(3):399-404
  18. van Berlo D, Haberzettl P, Gerloff K, Li H, Scherbart AM, Albrecht C, Schins RP. Investigation of the Cytotoxic and Proinflammatory Effects of Cement Dusts in Rat Alveolar Macrophages. Chem Res Toxicol. 2009 Aug 21. [Epub ahead of print]
  19. van Breda SG, van Delft JH, Engels LG, Kleinjans JC, Mathers JC. Methylation status of CpG islands in the promoter region of genes differentially expressed in colonic mucosa from adenoma patients and controls in response to altered vegetable intake. Br J Nutr. 2009 May;101(9):1295-9
  20. van Dartel DA, Zeijen NJ, de la Fonteyne LJ, van Schooten FJ, Piersma AH. Disentangling cellular proliferation and differentiation in the embryonic stem cell test, and its impact on the experimental protocol. Reprod Toxicol. 2009 Sep;28(2):254-61
  21. van Dartel DA, Pennings JL, Hendriksen PJ, van Schooten FJ, Piersma AH. Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate. Reprod Toxicol. 2009 Apr;27(2):93-102
  22. Vanhees K, de Bock L, van Schooten FJ, van Doorn-Khosrovani SB. The role of estrogenic compounds in the etiology of pediatric leukemia. Leuk Res. 2009 Nov;33(11):e210-1. Epub 2009 Jul 4.
  23. van Helden YG, Keijer J, Knaapen AM, Heil SG, Briedé JJ, van Schooten FJ, Godschalk RW. Beta-carotene metabolites enhance inflammation-induced oxidative DNA damage in lung epithelial cells. Free Radic Biol Med. 2009 Jan 15;46(2):299-304. Epub 2008 Oct 31
  24. van Helden YG, Keijer J, Heil SG, Picó C, Palou A, Oliver P, Munnia A, Briedé JJ, Peluso M, Hal NF, van Schooten FJ, Godschalk RW. Beta-carotene affects oxidative stress related DNA damage in lung epithelial cells and in ferret lung. Carcinogenesis. 2009 Jul 28
  25. van Leeuwen DM, Gottschalk RW, Schoeters G, van Larebeke NA, Nelen V, Baeyens WF, Kleinjans JC, van Delft JH Transcriptome analysis in peripheral blood of humans exposed to environmental carcinogens: a promising new biomarker in environmental health studies. Environ Health Perspect. 2008 Nov;116(11):1519-25.
  26. Verhagen H, te Boekhorst J, Kamps L, van Lieshout MJ, Ploeger H, Verreth D, Salminen S, van Loveren H. Novel foods: an explorative study into their grey area. Br J Nutr. 2009 May;101(9):1270-7. Epub 2009 Jan 28. Review.
  27. Verhofstad N, van Oostrom CT, van Benthem J, van Schooten FJ, van Steeg H, Godschalk RW. DNA adduct kinetics in reproductive tissues of DNA repair proficient and deficient male mice after oral exposure to benzo(a)pyrene. Environ Mol Mutagen. 2009 Jul 24
  28. Verstraeten VL, Caputo S, van Steensel MA, Duband-Goulet I, Zinn-Justin S, Kamps M, Kuijpers HJ, Ostlund C, Worman HJ, Briedé JJ, Le Dour C, Marcelis CL, van Geel M, Steijlen PM, van den Wijngaard A, Ramaekers FC, Broers JL. The R439C mutation in LMNA causes lamin oligomerization and susceptibility to oxidative stress. J Cell Mol Med. 2009 May;13(5):959-71
  29. Yu S, Kaneko Y, Bae E, Stahl CE, Wang Y, van Loveren H, Sanberg PR, Borlongan CV. Severity of controlled cortical impact traumatic brain injury in rats and mice dictates degree of behavioral deficits. Brain Res. 2009 Sep 1;1287:157-63.
  30. Dallinga JW, Robroeks CM, van Berkel JJ, Moonen EJ, Godschalk RW, Jöbsis Q, Dompeling E, Wouters EF, van Schooten FJ. Volatile organic compounds in exhaled breath as a diagnostic tool for asthma in children. Clin Exp Allergy. 2009 Sep 28. 
  31. De Jong WH, Arts JH, De Klerk A, Schijf MA, Ezendam J, Kuper CF, Van Loveren H. Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure. Toxicology. 2009 Jul 10;261(3):103-11
  32. de Kok TM, de Waard P, Wilms LC, van Breda SG. Antioxidative and antigenotoxic properties of vegetables and dietary phytochemicals: The value of genomics biomarkers in molecular epidemiology. Mol Nutr Food Res. 2009 Dec 18 
  33. de Vogel S, Wouters KA, Gottschalk RW, van Schooten FJ, de Goeij AF, de Bruïne AP, Goldbohm RA, van den Brandt PA, Weijenberg MP, van Engeland M. Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):3086-96. Epub 2009 Oct 20
  34. Ellinger-Ziegelbauer H, Aubrecht J, Kleinjans JC, Ahr HJ. Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity. Toxicol Lett. 2009 Apr 10;186(1):36-44. Review.
  35. Forchhammer L, Johansson C, Loft S, Möller L, Godschalk RW, Langie SA, Jones GD, Kwok RW, Collins AR, Azqueta A, Phillips DH, Sozeri O, Stepnik M, Palus J, Vogel U, Wallin H, Routledge MN, Handforth C, Allione A, Matullo G, Teixeira JP, Costa S, Riso P, Porrini M, Møller P.Variation in the measurement of DNA damage by comet assay measured by the ECVAG inter-laboratory validation trial. Mutagenesis. 2009 Nov 12. 
  36. Geraets L, Haegens A, Brauers K, Haydock JA, Vernooy JH, Wouters EF, Bast A, Hageman GJ. Inhibition of LPS-induced pulmonary inflammation by specific flavonoids. Biochem Biophys Res Commun. 2009 May 8;382(3):598-603. 
  37. Güngör N, Haegens A, Knaapen AM, Godschalk RW, Chiu RK, Wouters EF, van Schooten FJ Lung inflammation is associated with reduced pulmonary nucleotide excision repair in vivo. Mutagenesis. 2010 Jan;25(1):77-82. 
  38. Güngör N, Knaapen AM, Munnia A, Peluso M, Haenen GR, Chiu RK, Godschalk RW, van Schooten FJ. Genotoxic effects of neutrophils and hypochlorous acid. Mutagenesis. 2009 Nov 5.
  39. Hebels DG, Jennen DG, Kleinjans JC, de Kok TM. Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis. Toxicol Sci. 2009 Apr;108(2):290-300. 
  40. Hettne KM, Stierum RH, Schuemie MJ, Hendriksen PJ, Schijvenaars BJ, Mulligen EM, Kleinjans J, Kors JA. A dictionary to identify small molecules and drugs in free text. Bioinformatics. 2009 Nov 15;25(22):2983-91. 
  41. Houben JM, Mercken EM, Ketelslegers HB, Bast A, Wouters EF, Hageman GJ, Schols AM. Telomere shortening in chronic obstructive pulmonary disease. Respir Med. 2009 Feb;103(2):230-6
  42. Johansson C, Møller P, Forchhammer L, Loft S, Godschalk RW, Langie SA, Lumeij S, Jones GD, Kwok RW, Azqueta A, Phillips DH, Sozeri O, Routledge MN, Charlton AJ, Riso P, Porrini M, Allione A, Matullo G, Palus J, Stepnik M, Collins AR, Möller L.An ECVAG trial on assessment of oxidative damage to DNA measured by the comet assay.  Mutagenesis. 2009 Nov 30. 
  43. Ketelslegers HB, Godschalk RW, Eskens BJ, Dallinga JW, Gottschalk RW, van Schooten FJ, van Delft JH, Kleinjans JC Potential role of cytochrome P450-1B1 in the metabolic activation of 4-aminobiphenyl in humans. Mol Carcinog. 2009 Aug;48(8):685-91
  44. Keijer J, van Helden YG, Bunschoten A, van Schothorst EM. Transcriptome analysis in benefit-risk assessment of micronutrients and bioactive food components. Mol Nutr Food Res. 2009 Dec 18
  45. Kienhuis AS, van de Poll MC, Dejong CH, Gottschalk R, van Herwijnen M, Boorsma A, Kleinjans JC, Stierum RH, van Delft JH. A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo. Toxicol In Vitro. 2009 Sep;23(6):1163-9. 
  46. Langie SA, Kowalczyk P, Tudek B, Zabielski R, Dziaman T, Oliński R, van Schooten FJ, Godschalk RW. The effect of oxidative stress on nucleotide-excision repair in colon tissue of newborn piglets. Mutat Res. 2009 Dec 16. 
  47. Langie SA, Wilms LC, Hämäläinen S, Kleinjans JC, Godschalk RW, van Schooten FJ. Modulation of nucleotide excision repair in human lymphocytes by genetic and dietary factors. Br J Nutr. 2009 Nov 2:1-12.  
  48. Lankveld DP, Van Loveren H, Baken KA, Vandebriel RJ. In vitro testing for direct immunotoxicity: state of the art. Methods Mol Biol. 2010;598: 401-23.  Linschooten JO, Van Schooten FJ, Baumgartner A, Cemeli E, Van Delft J, Anderson D, Godschalk RW. Use of spermatozoal mRNA profiles to study gene-environment interactions in human germ cells. Mutat Res. 2009 Jul 10;667(1-2):70-6
  49. Mathijs K, Brauers KJ, Jennen DG, Boorsma A, van Herwijnen MH, Gottschalk RW, Kleinjans JC, van Delft JH. Discrimination for genotoxic and nongenotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time. Toxicol Sci. 2009 Dec;112(2):374-84. 
  50. Mathijs K, Kienhuis AS, Brauers KJ, Jennen DG, Lahoz A, Kleinjans JC, van Delft JH. Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes. Drug Metab Dispos. 2009 Jun;37(6):1305-11. 
  51. Mercken EM, Calvert LD, Singh SJ, Hageman GJ, Schols AM, Steiner MC. Dichloroacetate modulates the oxidative stress and inflammatory response to exercise in COPD. Chest. 2009 Sep;136(3):744-51.
  52. Mercken EM, Gosker HR, Rutten EP, Wouters EF, Bast A, Hageman GJ, Schols AM. Systemic and pulmonary oxidative stress after single-leg exercise in COPD. Chest. 2009 Nov;136(5):1291-300. 
  53. Mercken EM, Hageman GJ, Schols AM, Akkermans MA, Bast A, Wouters EF. Am J Respir Crit Care Med. 2005 Oct 15;172(8):994-1001.  
  54. Merlo DF, Wild CP, Kogevinas M, Kyrtopoulos S, Kleinjans J; NewGeneris Consortium. NewGeneris: a European study on maternal diet during pregnancy and child health. Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):5-10. 
  55. Osman AM, van Kol S, Peijnenburg A, Blokland M, Pennings JL, Kleinjans JC, van Loveren H. Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO). J Immunotoxicol. 2009 Sep;6(3):174-83.
  56. Park MV, Lankveld DP, van Loveren H, de Jong WH. The status of in vitro toxicity studies in the risk assessment of nanomaterials. Nanomed. 2009 Aug;4(6):669-85
  57. Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ. Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases? Eur Respir J. 2009 Mar;33(3):468-80. Review.
  58. Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ. Implications of gene-drug interactions in smoking cessation for improving the prevention of chronic degenerative diseases. Mutat Res. 2009 Jul 10;667(1-2):44-57
  59. Schnelle-Kreis J, Küpper U, Sklorz M, Cyrys J, Briedé JJ, Peters A, Zimmermann R. Daily measurement of organic compounds in ambient particulate matter in Augsburg, Germany: new aspects on aerosol sources and aerosol related health effects. Biomarkers. 2009 Jul;14 Suppl 1:39-44
  60. Theys J, Jutten B, Dubois L, Rouschop KM, Chiu RK, Li Y, Paesmans K, Lambin P, Lammering G, Wouters BG The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment. Radiother Oncol. 2009 Sep;92(3):399-404. Epub 2009 Jul 16
  61. Van Berkel JJ, Dallinga JW, Möller GM, Godschalk RW, Moonen EJ, Wouters EF, Van Schooten FJ.A profile of volatile organic compounds in breath discriminates COPD patients from controls. Respir Med. 2009 Nov 9. 
  62. Van Berlo D, Haberzettl P, Gerloff K, Li H, Scherbart AM, Albrecht C, Schins RP. Chem Res Toxicol. 2009;22:1548-58. Investigation of the cytotoxic and proinflammatory effects of cement dusts in rat alveolar macrophages (cf afspraak met Yvonne, FJ van Schooten is promotor van Damien van Berlo, Damien promoveert in 2010).
  63. van Breda SG, van Delft JH, Engels LG, Kleinjans JC, Mathers JC. Methylation status of CpG islands in the promoter region of genes differentially expressed in colonic mucosa from adenoma patients and controls in response to altered vegetable intake. Br J Nutr. 2009 May;101(9):1295-9
  64. van Dartel DA, Zeijen NJ, de la Fonteyne LJ, van Schooten FJ, Piersma AH. Disentangling cellular proliferation and differentiation in the embryonic stem cell test, and its impact on the experimental protocol. Reprod Toxicol. 2009 Sep;28(2):254-61. 
  65. van Dartel DA, Pennings JL, Hendriksen PJ, van Schooten FJ, Piersma AH. Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate. Reprod Toxicol. 2009 Apr;27(2):93-102.
  66. van der Ven LT, van de Kuil T, Leonards PE, Slob W, Lilienthal H, Litens S, Herlin M, Håkansson H, Cantón RF, van den Berg M, Visser TJ, van Loveren H, Vos JG, Piersma AH. Endocrine effects of hexabromocyclododecane (HBCD) in a one-generation reproduction study in Wistar rats. Toxicol Lett. 2009 Feb 25;185(1):51-62. 
  67. Vanhees K, de Bock L, van Schooten FJ, van Doorn-Khosrovani SB. The role of estrogenic compounds in the etiology of pediatric leukemia. Leuk Res. 2009 Nov;33(11):e210-1.
  68. van Helden YG, Keijer J, Heil SG, Picó C, Palou A, Oliver P, Munnia A, Briedé JJ, Peluso M, Franssen-van Hal NL, van Schooten FJ, Godschalk RW. Beta-carotene affects oxidative stress-related DNA damage in lung epithelial cells and in ferret lung. Carcinogenesis. 2009 Dec;30(12):2070-6. 
  69. van Helden YG, Keijer J, Knaapen AM, Heil SG, Briedé JJ, van Schooten FJ, Godschalk RW. Beta-carotene metabolites enhance inflammation-induced oxidative DNA damage in lung epithelial cells. Free Radic Biol Med. 2009 Jan 15;46(2):299-304
  70. Yvonne G.J. van Helden, Jaap Keijer, Catalina Pico, Andreu Palou, Jacob J. Briedé, Marco Peluso, Nicole Franssen-van Hal, Frederik J. van Schooten, Roger W. L. Godschalk. Beta-carotene affects oxidative stress related DNA damage in lung epithelial cells and in ferret lung. 2009; Carcinogenesis. 
  71. van Kesteren PC, Beems RB, Luijten M, Robinson J, de Vries A, van Steeg H. DNA repair-deficient Xpa/p53 knockout mice are sensitive to the non-genotoxic carcinogen cyclosporine A: escape of initiated cells from immunosurveillance? Carcinogenesis. 2009 Mar;30(3):538-43. 
  72. Verhagen H, te Boekhorst J, Kamps L, van Lieshout MJ, Ploeger H, Verreth D, Salminen S, van Loveren H. Br J Nutr. 2009 May;101(9):1270-7. Review.
  73. Verhofstad N, van Oostrom CT, van Benthem J, van Schooten FJ, van Steeg H, Godschalk RW. DNA adduct kinetics in reproductive tissues of DNA repair proficient and deficient male mice after oral exposure to benzo(a)pyrene. Environ Mol Mutagen. 2009 Jul 24
  74. Visschers VHM, Meertens RM, Passchier WF, de Vries NK. Probability Information in Risk Communication: A Review of the Research Literature. Risk Anal 2009;29(2):267-87.
  75. Weseler AR, Geraets L, Moonen HJ, Manders RJ, van Loon LJ, Pennings HJ, Wouters EF, Bast A, Hageman GJ. Poly (ADP-ribose) polymerase-1-inhibiting flavonoids attenuate cytokine release in blood from male patients with chronic obstructive pulmonary disease or type 2 diabetes. J Nutr. 2009 May;139(5):952-7. Epub 2009 Mar 25.
  76. Zainol M, Stoute J, Almeida GM, Rapp A, Bowman KJ, Jones GD; ECVAG (R.Godschalk is member of ECVAG). Introducing a true internal standard for the Comet assay to minimize intra- and inter-experiment variability in measures of DNA damage and repair. Nucleic Acids Res. 2009 Dec;37(22):e150.

 

 

Theses

Nejla Güngör. Role of neutrophils in pulmonary DNA damage and repair;

Jonathan de Jonge. Advancement of the brown Norway rat as a model for food allergy. Route of exposure - immunomodulation – allergogenomics;

Karen Mathijs. Evaluation of the primary mouse hepatocyte model for the prediction of genotoxicity.