This project aims to predict individual disease risk related to the environment, by characterizing the external and internal exposome for common exposures (air and drinking water contaminants) during critical periods of life, including in utero. A large amount of health data is now available from longitudinal cohorts in both children and adults, with detailed information on risk factors, confounders and outcomes, but these are not well linked with environmental exposure data. The exposome concept refers to the totality of environmental exposures from conception onwards, and is a novel approach to studying the role of the environment in human disease. This project will move the field forward by utilising data on individual external exposome (including sensors, smartphones, geo-referencing, satellites), and omic profiles in an agnostic search for new and integrated biomarkers. These tools will be applied in both experimental short-term studies and log-term longitudinal studies in humans. The ultimate goal is to use the new tools in risk assessment and in the estimation of the burden of environmental disease. The involvement of two SMEs, one specialized in sensors and smartphone development, the other in complex data integration, will increase the chances of a successful impact on European Public Health. This multidisciplinary proposal combines:
• development of a general framework for the systematic measurement of the internal and external exposome in Europe in relation to air and water contamination, as a way to reduce uncertainty in risk assessment and to address the effects of mixtures and complex exposures;
• evaluation of health outcomes and key physiological changes in short-term studies (including a randomized trial) and life-course studies with a large amount of information on diet, physical activity and anthropometry;
• evaluation of the burden of disease in the European population, based on state-of-the-art assessment of population exposures.
1 IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE, UK
2 UNIVERSITEIT UTRECHT, NL
3 CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER, FR
4 FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL – CREAL, ES
5 UNIVERSITEIT MAASTRICHT, NL
6 ETHNIKO IDRYMA EREVNON, EL
7 SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT, CH
8 KING'S COLLEGE LONDON, UK
9 GENEDATA AG, CH
10 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, US
11 UNIVERSITY OF BRISTOL, UK
12 CENTRE DE RECERCA I INNOVACIO DE CATALUNYA S.A., ES
Prof T de Kok PhD
Prof. Theo de Kok graduated in 1988 as biologist at the Catholic University of Nijmegen, The Netherlands, with Microbiology and Toxicology as maj more ...
RAJ Schlooz BSc
Rob Schlooz graduated in Business Economics in 2001 at the Hogeschool Zuyd. He has worked for a year at the administrative department of a hotel in Ma more ...
A Espín Pérez MSc
Almudena Espín Pérez, MSc, was born on June 21th 1989 in Murcia, Spain. In 2007 she started her degree study “Biotechnology” at Polytechnic University more ...
TRW Linssen BSc
Tom Linssen was born on December 14th 1990 in Nijmegen, the Netherlands. In 2011 he started his Bachelor in Bioinformatics at the University of Applie more ...
MHM van Herwijnen BSc
Marcel van Herwijnen studied common-microbiology at the technical school in Eindhoven. This study consists off different aspects such as microbiology, more ...