Department of Toxicogenomics

HeCaToS Hepatic and Cardiac Toxicity Systems modelling

HeCaToS aims at developing integrative in silico tools for predicting human liver and heart toxicity. The objective is to develop an integrated modeling framework, by combining advances in computational chemistry and systems toxicology, for modelling toxic perturbations in liver and heart across multiple scales. This framework will include vertical integrations of representations from drug(metabolite)-target interactions, through macromolecules/proteins, to (sub-)cellular functionalities and organ physiologies, and even the human whole-body level. In view of the importance of mitochondrial deregulations and of immunological dysfunctions associated with hepatic and cardiac drug-induced injuries, focus will be on these particular Adverse Outcome Pathways. Models will be populated with data from innovative in vitro 3D liver and heart assays challenged with prototypical hepato- or cardiotoxicants; data will be generated by advanced molecular and functional analytical techniques retrieving information on key (sub-)cellular toxic evens. For validating perturbed AOPs in vitro in appropriate human investigations, case studies on patients with liver injuries or cardiomyopathies due to adverse drug effects, will be developed, and biopsies will be subjected to similar analyses. Existing ChEMBL and diXa data infrastructures will be advanced for data gathering, storing and integrated statistical analysis.

Model performance in toxicity prediction will be assessed by comparing in silico predictions with experimental results across a multitude of read-out parameters, which in turn will suggest additional experiments for further validating predictions. HeCaToS, organized as a private-public partnership, will generate major socioeconomic impact because it will develop better chemical safety tests leading to safer drugs, but also industrial chemicals, and cosmetics, thereby improving patient and consumer health, and sustaining EU’s industrial competitiveness.

www.hecatos.eu

Associated Staff

Prof JCS Kleinjans PhD
Professor

Prof. Kleinjans studied biology at the Catholic University of Nijmegen and took a training in general biology and further trainings in physiological p more ...

T van den Beucken PhD
Assistant Professor

Dr. Twan van den Beucken studied technical microbiology at Fontys University of Applied Sciences in Venlo, were he graduated cum laude in 1998. In the more ...

RAJ Schlooz BSc
Project Manager

Rob Schlooz graduated in Business Economics in 2001 at the Hogeschool Zuyd. He has worked for a year at the administrative department of a hotel in Ma more ...

M Verheijen MSc
PhD Student

Marcha Verheijen was born on March 25th 1987 in Amersfoort, the Netherlands. At Leeuwenborgh Sittard, she studied ‘Chemical Laboratory Techniques’ fro more ...

TRW Linssen BSc
Bioinformatics Associate

Tom Linssen was born on December 14th 1990 in Nijmegen, the Netherlands. In 2011 he started his Bachelor in Bioinformatics at the University of Applie more ...

Y Schrooders MSc
Technician

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DHJ Theunissen MSc
former staff

Daniel Theunissen MSc was born 8th October 1983. Since then he earned his bachelor's degree in Molecular Life Sciences from the Transnationale Univers more ...