2017

  • Wong RH,Copeland WR,Jacob JT,Sivakanthan S,Van Gompel JJ,van Loveren H,Link MJ,Agazzi S Anterior Extension of Tumor is as Important as Tumor Size to Facial Nerve Outcome and Extent of Resection for Vestibular Schwannomas. Journal of neurological surgery. Part B, Skull base; 2017 Dec 29134166,10.1055/s-0037-1604331,160136,PMC5680033
  • Proquin H,Jetten MJ,Jonkhout MCM,Garduño-Balderas LG,Briedé JJ,de Kok TM,Chirino YI,van Loveren H Gene expression profiling in colon of mice exposed to food additive titanium dioxide (E171). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association; 2017 Nov 29128614,S0278-6915(17)30669-5,10.1016/j.fct.2017.11.011
  • Espín-Pérez A,Font-Ribera L,van Veldhoven K,Krauskopf J,Portengen L,Chadeau-Hyam M,Vermeulen R,Grimalt JO,Villanueva CM,Vineis P,Kogevinas M,Kleinjans JC,de Kok TM Blood transcriptional and microRNA responses to short-term exposure to disinfection by-products in a swimming pool. Environment international; 2018 Jan 29122314,S0160-4120(17)31182-0,10.1016/j.envint.2017.10.003
  • van Breda SGJ,de Kok TMCM Smart Combinations of Bioactive Compounds in Fruits and Vegetables May Guide New Strategies for Personalized Prevention of Chronic Diseases. Molecular nutrition & food research; 2017 Nov 29108107,10.1002/mnfr.201700597
  • Souza TM,Kleinjans JCS,Jennen DGJ Dose and Time Dependencies in Stress Pathway Responses during Chemical Exposure: Novel Insights from Gene Regulatory Networks. Frontiers in genetics; 2017 29085386,10.3389/fgene.2017.00142,PMC5649202
  • Germolec D,Luebke R,Rooney A,Shipkowski K,Vandebriel R,van Loveren H Immunotoxicology: A brief history, current status and strategies for future immunotoxicity assessment. Current opinion in toxicology; 2017 Aug 28989989,PMC5629009,NIHMS887641
  • Buesen R,Chorley BN,da Silva Lima B,Daston G,Deferme L,Ebbels T,Gant TW,Goetz A,Greally J,Gribaldo L,Hackermüller J,Hubesch B,Jennen D,Johnson K,Kanno J,Kauffmann HM,Laffont M,McMullen P,Meehan R,Pemberton M,Perdichizzi S,Piersma AH,Sauer UG,Schmidt K,Seitz H,Sumida K,Tollefsen KE,Tong W,Tralau T,van Ravenzwaay B,Weber RJM,Worth A,Yauk C,Poole A Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop. Regulatory toxicology and pharmacology : RTP; 2017 Sep 28958911,S0273-2300(17)30274-X,10.1016/j.yrtph.2017.09.002
  • Corvi R,Madia F,Guyton KZ,Kasper P,Rudel R,Colacci A,Kleinjans J,Jennings P Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop. Toxicology in vitro : an international journal published in association with BIBRA; 2017 Sep 28911985,S0887-2333(17)30262-X,10.1016/j.tiv.2017.09.010
  • Georgiadis P,Liampa I,Hebels DG,Krauskopf J,Chatziioannou A,Valavanis I,de Kok TMCM,Kleinjans JCS,Bergdahl IA,Melin B,Spaeth F,Palli D,Vermeulen RCH,Vlaanderen J,Chadeau-Hyam M,Vineis P,Kyrtopoulos SA, Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis. BMC genomics; 2017 Sep 28903739,10.1186/s12864-017-4117-4,10.1186/s12864-017-4117-4,PMC5598006
  • Brand W,Noorlander CW,Giannakou C,De Jong WH,Kooi MW,Park MV,Vandebriel RJ,Bosselaers IE,Scholl JH,Geertsma RE Nanomedicinal products: a survey on specific toxicity and side effects. International journal of nanomedicine; 2017 28883724,10.2147/IJN.S139687,ijn-12-6107,PMC5574663
  • Smit E,Souza T,Jennen DGJ,Kleinjans JCS,van den Beucken T Identification of essential transcription factors for adequate DNA damage response after benzo(a)pyrene and aflatoxin B1 exposure by combining transcriptomics with functional genomics. Toxicology; 2017 Sep 28882572,S0300-483X(17)30247-0,10.1016/j.tox.2017.09.002
  • Wolters JEJ,van Breda SGJ,Caiment F,Claessen SM,de Kok TMCM,Kleinjans JCS Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chemical research in toxicology; 2017 Oct 28853863,10.1021/acs.chemrestox.7b00171,PMC5645762
  • Kuepfer L,Clayton O,Thiel C,Cordes H,Nudischer R,Blank LM,Baier V,Heymans S,Caiment F,Roth A,Fluri DA,Kelm JM,Castell J,Selevsek N,Schlapbach R,Keun H,Hynes J,Sarkans U,Gmuender H,Herwig R,Niederer S,Schuchhardt J,Segall M,Kleinjans J A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity. Archives of toxicology; 2017 Aug 28852801,10.1007/s00204-017-2041-7,10.1007/s00204-017-2041-7
  • Plusquin M,Guida F,Polidoro S,Vermeulen R,Raaschou-Nielsen O,Campanella G,Hoek G,Kyrtopoulos SA,Georgiadis P,Naccarati A,Sacerdote C,Krogh V,Bas Bueno-de-Mesquita H,Monique Verschuren WM,Sayols-Baixeras S,Panni T,Peters A,Hebels DGAJ,Kleinjans J,Vineis P,Chadeau-Hyam M DNA methylation and exposure to ambient air pollution in two prospective cohorts. Environment international; 2017 Nov 28843141,S0160-4120(16)30980-1,10.1016/j.envint.2017.08.006
  • Krauskopf J,de Kok TM,Hebels DG,Bergdahl IA,Johansson A,Spaeth F,Kiviranta H,Rantakokko P,Kyrtopoulos SA,Kleinjans JC MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery. Scientific reports; 2017 Aug 28835693,10.1038/s41598-017-10167-7,10.1038/s41598-017-10167-7,PMC5569060
  • Jiang J,Mathijs K,Timmermans L,Claessen SM,Hecka A,Weusten J,Peters R,van Delft JH,Kleinjans JCS,Jennen DGJ,de Kok TM The idiosyncratic drug-induced gene expression changes in HepG2 cells. Data in brief; 2017 Oct 28831409,10.1016/j.dib.2017.07.074,S2352-3409(17)30376-1,PMC5554930
  • Lee S,Zhang C,Liu Z,Klevstig M,Mukhopadhyay B,Bergentall M,Cinar R,Ståhlman M,Sikanic N,Park JK,Deshmukh S,Harzandi AM,Kuijpers T,Grøtli M,Elsässer SJ,Piening BD,Snyder M,Smith U,Nielsen J,Bäckhed F,Kunos G,Uhlen M,Boren J,Mardinoglu A Network analyses identify liver-specific targets for treating liver diseases. Molecular systems biology; 2017 Aug 28827398,PMC5572395
  • Winckelmans E,Nawrot TS,Tsamou M,Den Hond E,Baeyens W,Kleinjans J,Lefebvre W,Van Larebeke N,Peusens M,Plusquin M,Reynders H,Schoeters G,Vanpoucke C,de Kok TM,Vrijens K Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure. Environmental health : a global access science source; 2017 Aug 28821289,10.1186/s12940-017-0292-7,10.1186/s12940-017-0292-7,PMC5563023
  • Van den Hof WFPM,Coonen MLJ,van Herwijnen M,Brauers K,Jennen D,Olde Damink SWM,Schaap FG,Kleinjans JCS Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis. Toxicology in vitro : an international journal published in association with BIBRA; 2017 Oct 28778767,S0887-2333(17)30210-2,10.1016/j.tiv.2017.07.024
  • Ertaylan G,Le Cornet C,van Roekel EH,Jung AY,Bours MJL,Damms-Machado A,van den Brandt PA,Schock H,de Kok TM,Theys J,Arts ICW,Kaaks R,Weijenberg MP,Fortner RT A Comparative Study on the WCRF International/University of Bristol Methodology for Systematic Reviews of Mechanisms Underpinning Exposure-Cancer Associations. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology; 2017 Nov 28754794,1055-9965.EPI-17-0230,10.1158/1055-9965.EPI-17-0230
  • Souza TM,van den Beucken T,Kleinjans JCS,Jennen DGJ Inferring transcription factor activity from microarray data reveals novel targets for toxicological investigations. Toxicology; 2017 Aug 28743512,S0300-483X(17)30197-X,10.1016/j.tox.2017.07.008
  • Jiang J,Mathijs K,Timmermans L,Claessen SM,Hecka A,Weusten J,Peters R,van Delft JH,Kleinjans JCS,Jennen DGJ,de Kok TM Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury. Toxicology and applied pharmacology; 2017 Oct 28733206,S0041-008X(17)30311-3,10.1016/j.taap.2017.07.014
  • De Jong HJI,van Staa TP,Lalmohamed A,de Vries F,Vandebriel RJ,Van Loveren H,Klungel OH,Cohen Tervaert JW Pattern of risks of systemic lupus erythematosus among statin users: a population-based cohort study. Annals of the rheumatic diseases; 2017 Oct 28684558,annrheumdis-2016-210936,10.1136/annrheumdis-2016-210936
  • Portier CJ,Clausing P Re: Tarazona et al. (2017): Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC. doi: 10.1007/s00204-017-1962-5. Archives of toxicology; 2017 Jun 28620672,10.1007/s00204-017-2009-7,10.1007/s00204-017-2009-7
  • Winckelmans E,Vrijens K,Tsamou M,Janssen BG,Saenen ND,Roels HA,Kleinjans J,Lefebvre W,Vanpoucke C,de Kok TM,Nawrot TS Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort. Environmental health : a global access science source; 2017 Jun 28583124,10.1186/s12940-017-0264-y,10.1186/s12940-017-0264-y,PMC5458481
  • Apte JS,Messier KP,Gani S,Brauer M,Kirchstetter TW,Lunden MM,Marshall JD,Portier CJ,Vermeulen RCH,Hamburg SP High-Resolution Air Pollution Mapping with Google Street View Cars: Exploiting Big Data. Environmental science & technology; 2017 Jun 28578585,10.1021/acs.est.7b00891
  • Krauskopf J,de Kok TM,Schomaker SJ,Gosink M,Burt DA,Chandler P,Warner RL,Johnson KJ,Caiment F,Kleinjans JC,Aubrecht J Serum microRNA signatures as "liquid biopsies" for interrogating hepatotoxic mechanisms and liver pathogenesis in human. PloS one; 2017 28545106,10.1371/journal.pone.0177928,PONE-D-17-09000,PMC5435338
  • Gielis JF,Quirynen L,Briedé JJ,Roelant E,Cos P,Van Schil PEY Pathogenetic role of endothelial nitric oxide synthase uncoupling during lung ischaemia-reperfusion injury. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery; 2017 Aug 28481990,3805118,10.1093/ejcts/ezx125
  • Gielis JF,Beckers PAJ,Briedé JJ,Cos P,Van Schil PE Oxidative and nitrosative stress during pulmonary ischemia-reperfusion injury: from the lab to the OR. Annals of translational medicine; 2017 Mar 28462211,10.21037/atm.2017.03.32,atm-05-06-131,PMC5395487
  • McPartland J,Dantzker H,Portier C Elucidating environmental dimensions of neurological disorders and disease: Understanding new tools from federal chemical testing programs. The Science of the total environment; 2017 Sep 28364604,S0048-9697(17)30529-6,10.1016/j.scitotenv.2017.03.024
  • Vlaanderen J,Leenders M,Chadeau-Hyam M,Portengen L,Kyrtopoulos SA,Bergdahl IA,Johansson AS,Hebels DD,de Kok TM,Vineis P,Vermeulen RC Exploring the nature of prediagnostic blood transcriptome markers of chronic lymphocytic leukemia by assessing their overlap with the transcriptome at the clinical stage. BMC genomics; 2017 Mar 28320322,10.1186/s12864-017-3627-4,10.1186/s12864-017-3627-4,PMC5360061
  • Chatziioannou A,Georgiadis P,Hebels DG,Liampa I,Valavanis I,Bergdahl IA,Johansson A,Palli D,Chadeau-Hyam M,Siskos AP,Keun H,Botsivali M,de Kok TM,Pérez AE,Kleinjans JC,Vineis P,Kyrtopoulos SA, Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases. Scientific reports; 2017 Feb 28225026,srep42870,10.1038/srep42870,PMC5320491
  • Kelly RS,Kiviranta H,Bergdahl IA,Palli D,Johansson AS,Botsivali M,Vineis P,Vermeulen R,Kyrtopoulos SA,Chadeau-Hyam M, Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study. Environmental health : a global access science source; 2017 Feb 28202064,10.1186/s12940-017-0214-8,10.1186/s12940-017-0214-8,PMC5312563
  • Mostafavi N,Vlaanderen J,Portengen L,Chadeau-Hyam M,Modig L,Palli D,Bergdahl IA,Brunekreef B,Vineis P,Hebels DG,Kleinjans JC,Krogh V,Hoek G,Georgiadis P,Kyrtopoulos S,Vermeulen R Associations Between Genome-wide Gene Expression and Ambient Nitrogen Oxides. Epidemiology (Cambridge, Mass.); 2017 May 28151741,10.1097/EDE.0000000000000628
  • Hendrickx DM,Souza T,Jennen DGJ,Kleinjans JCS DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds. Archives of toxicology; 2017 Jun 28032149,10.1007/s00204-016-1922-5,10.1007/s00204-016-1922-5,PMC5429357
  • Escher BI,Hackermüller J,Polte T,Scholz S,Aigner A,Altenburger R,Böhme A,Bopp SK,Brack W,Busch W,Chadeau-Hyam M,Covaci A,Eisenträger A,Galligan JJ,Garcia-Reyero N,Hartung T,Hein M,Herberth G,Jahnke A,Kleinjans J,Klüver N,Krauss M,Lamoree M,Lehmann I,Luckenbach T,Miller GW,Müller A,Phillips DH,Reemtsma T,Rolle-Kampczyk U,Schüürmann G,Schwikowski B,Tan YM,Trump S,Walter-Rohde S,Wambaugh JF From the exposome to mechanistic understanding of chemical-induced adverse effects. Environment international; 2017 Feb 27939949,S0160-4120(16)30918-7,10.1016/j.envint.2016.11.029
  • Proquin H,Rodríguez-Ibarra C,Moonen CG,Urrutia Ortega IM,Briedé JJ,de Kok TM,van Loveren H,Chirino YI Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions. Mutagenesis; 2017 Jan 27789654,gew051,10.1093/mutage/gew051
  • Souza TM,Rieswijk L,Beucken TV,Kleinjans J,Jennen D Persistent transcriptional responses show the involvement of feed-forward control in a repeated dose toxicity study. Toxicology; 2017 Jan 27765683,S0300-483X(16)30245-1,10.1016/j.tox.2016.10.009
  • Vrijens K,Winckelmans E,Tsamou M,Baeyens W,De Boever P,Jennen D,de Kok TM,Den Hond E,Lefebvre W,Plusquin M,Reynders H,Schoeters G,Van Larebeke N,Vanpoucke C,Kleinjans J,Nawrot TS Sex-Specific Associations between Particulate Matter Exposure and Gene Expression in Independent Discovery and Validation Cohorts of Middle-Aged Men and Women. Environmental health perspectives; 2017 Apr 27740511,10.1289/EHP370,EHP370,PMC5381989
  • Boei JJWA,Vermeulen S,Klein B,Hiemstra PS,Verhoosel RM,Jennen DGJ,Lahoz A,Gmuender H,Vrieling H Xenobiotic metabolism in differentiated human bronchial epithelial cells. Archives of toxicology; 2017 May 27738743,10.1007/s00204-016-1868-7,10.1007/s00204-016-1868-7,PMC5399058
  • Vineis P,Chadeau-Hyam M,Gmuender H,Gulliver J,Herceg Z,Kleinjans J,Kogevinas M,Kyrtopoulos S,Nieuwenhuijsen M,Phillips DH,Probst-Hensch N,Scalbert A,Vermeulen R,Wild CP, The exposome in practice: Design of the EXPOsOMICS project. International journal of hygiene and environmental health; 2017 Mar 27576363,S1438-4639(16)30130-4,10.1016/j.ijheh.2016.08.001
  • O'Callaghan-Gordo C,Kogevinas M,Fthenou E,Pedersen M,Espinosa A,Chalkiadaki G,Daraki V,Dermitzaki E,Decordier I,Georgiou V,Merlo DF,Roumeliotaki T,Vande Loock K,Kleinjans J,Kirsch-Volders M,Chatzi L Vitamin D insufficient levels during pregnancy and micronuclei frequency in peripheral blood T lymphocytes mothers and newborns (Rhea cohort, Crete). Clinical nutrition (Edinburgh, Scotland); 2017 Aug 27396287,S0261-5614(16)30150-9,10.1016/j.clnu.2016.06.016
  • Sand S,Parham F,Portier CJ,Tice RR,Krewski D Comparison of Points of Departure for Health Risk Assessment Based on High-Throughput Screening Data. Environmental health perspectives; 2017 Apr 27384688,10.1289/EHP408,EHP408,PMC5381992