2019

Proquin H,Jonkhout MCM,Jetten MJ,van Loveren H,de Kok TM,Briedé JJ Transcriptome changes in undifferentiated Caco-2 cells exposed to food-grade titanium dioxide (E171): contribution of the nano- and micro- sized particles. Scientific reports; 2019 Dec 31797963,10.1038/s41598-019-54675-0,10.1038/s41598-019-54675-0,PMC6893026
Krewski D,Rice JM,Bird M,Milton B,Collins B,Lajoie P,Billard M,Grosse Y,Cogliano VJ,Caldwell JC,Rusyn II,Portier CJ,Melnick RL,Baan RA,Little J,Zielinski JM Concordance between sites of tumor development in humans and in experimental animals for 111 agents that are carcinogenic to humans. Journal of toxicology and environmental health. Part B, Critical reviews; 2019 31795923,10.1080/10937404.2019.1642586
Dertinger SD,Totsuka Y,Bielas JH,Doherty AT,Kleinjans J,Honma M,Marchetti F,Schuler MJ,Thybaud V,White P,Yauk CL High information content assays for genetic toxicology testing: A report of the International Workshops on Genotoxicity Testing (IWGT). Mutation research; 2019 Nov 31699343,S1383-5718(18)30411-X,10.1016/j.mrgentox.2019.02.003
van Breda SG,Mathijs K,Sági-Kiss V,Kuhnle GG,van der Veer B,Jones RR,Sinha R,Ward MH,de Kok TM Impact of high drinking water nitrate levels on the endogenous formation of apparent N-nitroso compounds in combination with meat intake in healthy volunteers. Environmental health : a global access science source; 2019 10 31623611,10.1186/s12940-019-0525-z,10.1186/s12940-019-0525-z,PMC6796425
Jiang J,Pieterman CD,Ertaylan G,Peeters RLM,de Kok TMCM The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro. Archives of toxicology; 2019 Nov 31586243,10.1007/s00204-019-02585-5,10.1007/s00204-019-02585-5
O'Donovan SD,Lenz M,Vink RG,Roumans NJT,de Kok TMCM,Mariman ECM,Peeters RLM,van Riel NAW,van Baak MA,Arts ICW A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data. PLoS computational biology; 2019 10 31581241,10.1371/journal.pcbi.1007400,PCOMPBIOL-D-19-00282,PMC6890259
Hiemstra S,Ramaiahgari SC,Wink S,Callegaro G,Coonen M,Meerman J,Jennen D,van den Nieuwendijk K,Dankers A,Snoeys J,de Bont H,Price L,van de Water B High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability. Archives of toxicology; 2019 Oct 31552476,10.1007/s00204-019-02552-0,10.1007/s00204-019-02552-0
Tareen SH,Kutmon M,Arts IC,de Kok TM,Evelo CT,Adriaens ME Logical modelling reveals the PDC-PDK interaction as the regulatory switch driving metabolic flexibility at the cellular level. Genes & nutrition; 2019 31516637,10.1186/s12263-019-0647-5,647,PMC6734263
Stassen FRM,van Eijck PH,Savelkoul PHM,Wouters EFM,Rohde GGU,Briedé JJ,Reynaert NL,de Kok TM,Benedikter BJ Cell Type- and Exposure-Specific Modulation of CD63/CD81-Positive and Tissue Factor-Positive Extracellular Vesicle Release in response to Respiratory Toxicants. Oxidative medicine and cellular longevity; 2019 31485294,10.1155/2019/5204218,PMC6710792
Lewalle A,Land S,Merken JJ,Raafs A,Sepúlveda P,Heymans S,Kleinjans J,Niederer SA Balance of Active, Passive, and Anatomical Cardiac Properties in Doxorubicin-Induced Heart Failure. Biophysical journal; 2019 Dec 31447110,S0006-3495(19)30622-8,10.1016/j.bpj.2019.07.033,PMC6990149
Kuijpers TJM,Wolters JEJ,Kleinjans JCS,Jennen DGJ DynOVis: a web tool to study dynamic perturbations for capturing dose-over-time effects in biological networks. BMC bioinformatics; 2019 Aug 31409281,10.1186/s12859-019-2995-y,10.1186/s12859-019-2995-y,PMC6693283
Bohler S,Liu X,Krauskopf J,Caiment F,Aubrecht J,Nicolaes GAF,Kleinjans JCS,Briedé JJ Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease. Clinical and translational science; 2019 Nov 31305025,10.1111/cts.12663,PMC6853143
Rodrigues D,Souza T,Jennen DGJ,Lemmens L,Kleinjans JCS,de Kok TM Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches. Cancer treatment reviews; 2019 Jul 31279169,S0305-7372(19)30082-9,10.1016/j.ctrv.2019.06.004
Sillivan SE,Jamieson S,de Nijs L,Jones M,Snijders C,Klengel T,Joseph NF,Krauskopf J,Kleinjans J,Vinkers CH,Boks MPM,Geuze E,Vermetten E,Berretta S,Ressler KJ,Rutten BPF,Rumbaugh G,Miller CA Correction: MicroRNA regulation of persistent stress-enhanced memory. Molecular psychiatry; 2019 Jun 31253953,10.1038/s41380-019-0452-y,10.1038/s41380-019-0452-y
O'Donovan SD,Lenz M,Goossens GH,van der Kallen CJH,Eussen SJMP,Stehouwer CDA,van Greevenbroek MM,Schram MT,Sep SJ,Peeters RLM,Blaak EE,van Riel NAW,de Kok TMCM,Arts ICW Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator. Scientific reports; 2019 Jun 31253846,10.1038/s41598-019-45858-w,10.1038/s41598-019-45858-w,PMC6598992
Sillivan SE,Jamieson S,de Nijs L,Jones M,Snijders C,Klengel T,Joseph NF,Krauskopf J,Kleinjans J,Vinkers CH,Boks MPM,Geuze E,Vermetten E,Berretta S,Ressler KJ,Rutten BPF,Rumbaugh G,Miller CA MicroRNA regulation of persistent stress-enhanced memory. Molecular psychiatry; 2019 May 31142820,10.1038/s41380-019-0432-2,10.1038/s41380-019-0432-2,PMC6883139,NIHMS1526902
Giannakou C,Aimonen K,Bloois LV,Catalán J,Geertsma RE,Gremmer ER,de Jong WH,Keizers PH,Schwillens PL,Vandebriel RJ,Park MV Sensitive method for endotoxin determination in nanomedicinal product samples. Nanomedicine (London, England); 2019 05 31124759,10.2217/nnm-2018-0339
Cox B,Tsamou M,Vrijens K,Neven KY,Winckelmans E,de Kok TM,Plusquin M,Nawrot TS A Co-expression Analysis of the Placental Transcriptome in Association With Maternal Pre-pregnancy BMI and Newborn Birth Weight. Frontiers in genetics; 2019 31110514,10.3389/fgene.2019.00354,PMC6501552
Espina C,Bauld L,Bonanni B,Brenner H,Brown K,Dillner J,Kampman E,Nilbert M,Vineis P,Weijenberg MP,Cox A,de Kok TM,Fecht D,Mitrou G,Muller DC,Serrano D,Steindorf K,Storm H,Thorat MA,van Duijnhoven F,Weiderpass E,Schüz J WITHDRAWAL-Administrative Duplicate Publication: The essential role of prevention in reducing the cancer burden in Europe: a commentary from Cancer Prevention Europe. Tumori; 2019 May 31099306,10.1177/0300891619851865
Berends JE,van den Berg LMM,Guggeis MA,Henckens NFT,Hossein IJ,de Joode MEJR,Zamani H,van Pelt KAAJ,Beelen NA,Kuhnle GG,de Kok TMCM,Van Breda SGJ Consumption of Nitrate-Rich Beetroot Juice with or without Vitamin C Supplementation Increases the Excretion of Urinary Nitrate, Nitrite, and -nitroso Compounds in Humans. International journal of molecular sciences; 2019 May 31072023,ijms20092277,10.3390/ijms20092277,PMC6539140
Krauskopf J,van Veldhoven K,Chadeau-Hyam M,Vermeulen R,Carrasco-Turigas G,Nieuwenhuijsen M,Vineis P,de Kok TM,Kleinjans JC Short-term exposure to traffic-related air pollution reveals a compound-specific circulating miRNA profile indicating multiple disease risks. Environment international; 2019 07 31059914,S0160-4120(19)30393-9,10.1016/j.envint.2019.04.063
Jiang J,Messner S,Kelm JM,van Herwijnen M,Jennen DGJ,Kleinjans JC,de Kok TM Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. Toxicology letters; 2019 Sep 31059760,S0378-4274(19)30137-7,10.1016/j.toxlet.2019.05.004
Reimann B,Janssen BG,Alfano R,Ghantous A,Espín-Pérez A,de Kok TM,Saenen ND,Cox B,Robinson O,Chadeau-Hyam M,Penders J,Herceg Z,Vineis P,Nawrot TS,Plusquin M The Cord Blood Insulin and Mitochondrial DNA Content Related Methylome. Frontiers in genetics; 2019 31031804,10.3389/fgene.2019.00325,PMC6474284
Bohler S,Krauskopf J,Espín-Pérez A,Gebel S,Palli D,Rantakokko P,Kiviranta H,Kyrtopoulos SA,Balling R,Kleinjans J Genes associated with Parkinson's disease respond to increasing polychlorinated biphenyl levels in the blood of healthy females. Environmental pollution (Barking, Essex : 1987); 2019 Jul 30991279,S0269-7491(18)34459-2,10.1016/j.envpol.2019.04.005
Verheijen M,Lienhard M,Schrooders Y,Clayton O,Nudischer R,Boerno S,Timmermann B,Selevsek N,Schlapbach R,Gmuender H,Gotta S,Geraedts J,Herwig R,Kleinjans J,Caiment F DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro. Scientific reports; 2019 Mar 30874586,10.1038/s41598-019-40660-0,10.1038/s41598-019-40660-0,PMC6420634
Georgiadis P,Gavriil M,Rantakokko P,Ladoukakis E,Botsivali M,Kelly RS,Bergdahl IA,Kiviranta H,Vermeulen RCH,Spaeth F,Hebbels DGAJ,Kleinjans JCS,de Kok TMCM,Palli D,Vineis P,Kyrtopoulos SA, DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia. Environment international; 2019 05 30776747,S0160-4120(18)32586-8,10.1016/j.envint.2019.01.068
Espín-Pérez A,Hebels DGAJ,Kiviranta H,Rantakokko P,Georgiadis P,Botsivali M,Bergdahl IA,Palli D,Späth F,Johansson A,Chadeau-Hyam M,Kyrtopoulos SA,Kleinjans JCS,de Kok TMCM Identification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs). Scientific reports; 2019 Jan 30679748,10.1038/s41598-018-37449-y,10.1038/s41598-018-37449-y,PMC6346099
Smit E,Kleinjans JCS,van den Beucken T Phosphorylation of eIF2α promotes cell survival in response to benzo[a]pyrene exposure. Toxicology in vitro : an international journal published in association with BIBRA; 2019 Feb 30385349,S0887-2333(18)30214-5,10.1016/j.tiv.2018.10.015