BReIN - Brightlands e-Infrastructure for Neurohealth BReIN

Overall objectives of the research program

The onset of Alzheimer's Disease (AD) can only be directly attributed to genetic predisposition or genetic factors in approximately 10% of cases. The assumption is therefore that the large majority of cases (sporadic AD) is caused by harmful environmental factors. However, very little is known about this. More insight into the molecular mechanisms by which such environmental factors cause AD will enable better and earlier diagnostics, more effective pharmacotherapy and optimized preventive strategies. This offers great opportunities for innovation and valorisation.

BReIN's research program therefore aims at a better understanding of the role of harmful environmental factors in the development and progression of AD. It will also be investigated whether there is a greater sensitivity to these adverse environmental factors in certain AD patients.

In order to unravel these molecular mechanisms, given the complexity of the neuronal systems involved, with sufficient depth, BReIN uses very powerful 'omics technologies with a high resolution in analyzing molecular processes. This concerns in particular 'next generation sequencing' (NGS), supplemented with 'imaging' data (CT, MRI, PET). The DNA / RNA analyzes will be performed - post mortem in brain tissue, as well as at different stages of the course of the disease in blood and cerebrospinal fluid (CSF) - in patients with sporadic AD. NGS analyzes will also be used in experimental in vitro research in which pluripotent stem cell models (iPSC) will investigate the role of chemical environmental factors in particular. The iPSCs will be cultured in such a way that they differentiate into the appropriate phenotype for AD. Results of this mechanistic in vitro study in iPSC AD models will be linked translationally with data from sporadic AD patients.

BReIN will therefore generate very large quantities of molecular data that will also be supplemented with MRI scans from AD patients. This requires that a tailored data infrastructure is created within which data are stored reliably, standardized and sustainably and which enables conducting  the more complex statistical and mathematical analyses that are relevant for disclosing  molecular mechanisms induced by chemical environmental factors.

The central objective of the BReIN research is therefore to perform translational mechanistic research on the involvement of adverse environmental factors in the development of sporadic AD and to create a new e-Infrastructure for the collection, storage and integrative analysis of multiple complex data types thus enabling to design strategies for diagnosis, therapy and prevention.

Associated Staff

Prof Jos CS Kleinjans PhD
Professor

Prof. Kleinjans studied biology at the Catholic University of Nijmegen and took a training in general biology and further trainings in physiological p more ...

Duncan Hauser BSc
Technician

Duncan Hauser was born August 16th, in Chicago, Illinois, USA. He received his bachelor’s degree in Biology in 2012 from Lewis & Clark College in more ...

Danyel GJ Jennen PhD
Associate Professor

Dr. Danyel Jennen is Associate Professor in the field of toxicoinformatics at the UM Department of Toxicogenomics and he heads its core unit on toxico more ...

Florian Caiment PhD
Assistant Professor

Dr. Florian Caiment was born on the 15th of August 1980 in Troyes, France. After studying general biology in Reims then Nancy universities (France), h more ...

Twan van den Beucken PhD
Assistant Professor

Dr. Twan van den Beucken studied technical microbiology at Fontys University of Applied Sciences in Venlo, were he graduated cum laude in 1998. In the more ...

Jumamyrat Bayjanov PhD
Postdoctoral Fellow

Dr. Jumamurat Bayjanov obtained his PhD in 2012 in the field of bioinformatics from Radboud University, the Netherlands. There he developed bioinforma more ...

Julian Krauskopf PhD
Postdoctoral Fellow

Julian Krauskopf studied bioinformatics at the Goethe University Frankfurt and the University of Applied Sciences Gießen where he graduated in M more ...

Rob AJ Schlooz BSc
Project Manager

Rob Schlooz graduated in Business Economics in 2001 at the Hogeschool Zuyd. He has worked for a year at the administrative department of a hotel in Ma more ...