Enhanced cross-omics visualizations in toxicogenomics

In this project the main objective is to obtain more insight in the biological processes underlying the exposure of a cell model to a (toxic) substance. These biological processes are often dynamic, and thus their activity should be monitored at multiple time points. Therefore, this dynamic activity will be captured by monitoring gene expression, miRNA and epigenetic changes at multiple time points using RNA-seq and MeDIP-seq. In addition, multiple phenotypic endpoints are being measured as well in these time-series experiments.

Different statistical and mathematical models as well as visualization tools will be applied to achieve the objective. Developing or improving/adjusting methods for data integration, capturing time dependencies/time delays and causality will be part of this project.

Associated Staff

Prof Jos CS Kleinjans PhD
Professor

Prof. Kleinjans studied biology at the Catholic University of Nijmegen and took a training in general biology and further trainings in physiological p more ...

Danyel GJ Jennen PhD
Assistant Professor

Dr. Danyel Jennen is Assistant Professor in the field of toxicoinformatics at the UM Department of Toxicogenomics and he heads its core unit on toxico more ...

Tim JM Kuijpers MSc
PhD Student

Tim Kuijpers was born on February 8th, 1988 in ‘s-Hertogenbosch, the Netherlands. He got his bachelor degree in the field of biomedical engineering at more ...