NTC An applied system biology approach to predict chemical safetyfinalized
Cancer, the second leading cause of death in the Western world, is primarily caused by genome instability. Genomic instability is usually associated as the result of toxicological interactions between several chemical compounds and the cell DNA content. Nevertheless, there are still many compounds with unclear or unidentified toxicological properties. This is of concern since there is an increase in the number of compounds synthesized by the pharmaceutical, chemical, cosmetic and food industries to which humans might be exposed. Therefore the well-established chemical safety of these substances is of crucial importance to be tested.
This is a project from the Netherlands Toxicogenomics Centre in which several institutions work together to achieve the desired system biology approach. The interaction between the partners will focus in the integration of data generated from several highly sensitive methodologies such as the ones used in genomic, metabolomic, proteomics and bioinformatic areas. In particular this Postdoctoral fellow focuses on the genomic analysis (mRNA and miRNA) from several substances by different in vitro and in vivo models, particularly in the context of liver toxicity. The identification of genes that cause sensitivity for genotoxic carcinogens as well the transcription factor regulated genes by genotoxic compounds is also programmed. Thereafter the in vitro and in vivo findings will be translated to human subjects, in order to determine biomarkers in relevant in vivo models and material of patients exposed to carcinogenic drugs. This will lead to establish mechanism-based high-content in vitro and sensitive in vivo reporter models for the prediction of carcinogen hazard.
In general, this project will strive to efficiently decipher biological pathway and the mechanistic drivers of toxicity that will ultimately be used to build a suite of “systems toxicology” models. These models will be the basis for the development of expertise and tools for aiding mechanistic and predictive toxicology.
Prof Jos CS Kleinjans PhD
Prof. Kleinjans studied biology at the Catholic University of Nijmegen and took a training in general biology and further trainings in physiological p more ...
Prof Henk van Loveren PhD
Prof. Van Loveren studied biology at the Utrecht University, where he graduated in 1975. His PhD study was also done at the Utrecht University (Facult more ...
René JHM Reijnders Drs
Rene Reijnders graduated in Health Sciences in 1992 at the Maastricht University (The Netherlands). After that he joined the Department of Epidemiolog more ...
Danyel GJ Jennen PhD
Dr. Danyel Jennen is Associate Professor in the field of toxicoinformatics at the UM Department of Toxicogenomics and he heads its core unit on toxico more ...