Prof Jos CS Kleinjans PhD
event_seat Professor

Environmental Health Science

phone +31-43-3881096
account_balance UNS40 K5.577

Prof. Kleinjans studied biology at the Catholic University of Nijmegen and took a training in general biology and further trainings in physiological psychology, pharmacology, neuro-anatomy, and chemical cytology. Immediately after his graduation in 1979, he started working as a PhD student at the Department of Pharmacology of the Faculty of Medicine of Maastricht University.

In 1983, he obtained his PhD degree for his thesis 'Stimulation of renal adrenergic mechanisms as a model for the development of hypertension'. A few months before, he had started to work as a Postdoctoral Research Fellow at the Department of Biological Health Science of the Faculty of Health Sciences of the same University. His research interests were project development in relation to human nutrition and project development and project management concerning nutritional toxicology. In addition, he was involved in the development of curricula and training courses in biological health.

In 1986, he was appointed Associate Professor at the Department of Biological Health Science, where he performed research tasks of programme management in nutritional toxicology and programme development regarding environmental health sciences as well as educational tasks described earlierextended with the development of curricula concerning environmental health sciences.

In 1991, he was appointed Full Professor of Environmental Health Science, head of the Department of Health Risk Analysis and Toxicology, and director of the interfaculty research programme Health and Environment of the Faculties of Health Sciences and Medicine.

Prof. Kleinjans was acknowledged as a pharmacologist by the Concilium Pharmacologicum on behalf of the Foundation for the training of Medical-Biological Scientific Researchers (SMBWO) in 1985 and as a toxicologist in 1988. He is a member of the Netherlands Society of Toxicology (Genetic Toxicology Section and In Vitro Toxicology Section), the Netherlands Society of Environmental Medicine, the Netherlands Society of Environmental Sciences, the Belgian Society of Toxicology, the European Environmental Mutagen Society, the Interuniversity Commission for Environmental Sciences of the Society of Cooperating Dutch Universities, and the Commission on Criteria Documents of the Dutch Health Council. Prof. Kleinjans, furthermore, is a consultant for governmental and non-governmental organizations on an incidental basis and author of national and international training courses in toxicology.

Associated Projects

Brain miRNA’s as markers of drug induced changes in neural integrity

Testing mechanistic and placebo-controlled studies in which we will administer a psychedelic drug (i.e. psilocybin) that is known to affect neural integrity More »

Enhanced cross-omics visualizations in toxicogenomics

More »


Animal-free hazard and risk assessment of chemicals More »


Hepatic and Cardiac Toxicity Systems modelling More »


Towards an earlier diagnosis of Alzheimers Disease (AD) More »


Analysis of Environmental-Genome Interactions in the development of neurodegenerative diseases More »


Open e-Infrastructure to Support Data Sharing, Knowledge Integration and in silico Analysis and Modelling in Risk Assessment More »


Translational quantitative systems toxicology to improve the understanding of the safety of medicines More »

APAP induced liver injury (DILI) finalized

"Drug Induced Liver Injuries: Studying the underlying mechanisms" More »

ASAT2 finalized

Systems toxicology supported data infrastructure for human risk assessment More »

BaP finalized

BaP-induced hepatocarcinogenesis More »

BE BASIC finalized

Biobased solutions for a sustainable society More »

Detective finalized

Detection of endpoints and biomarkers of repeated dose toxicity using in vitro systems More »

diXa finalized

Data Infrastructure for Chemical Safety More »

EnviroGenomarkers finalized

Genomics biomarkers of environmental health More »

Exposomics finalized

More »

Hepatocarcinogenesis finalized

Gene expression profiling of oxidative genotoxic compounds in hepatocarcinogenesis More »

iCORDI finalized

International Collaboration on Research Data Infrastructure More »

MeDIP seq finalized

Methylated DNA Immunoprecipitation Sequencing More »

NTC finalized

An applied system biology approach to predict chemical safety More »