Publications
2012
1: Schmeits PC, Volger OL, Zandvliet ET, van Loveren H, Peijnenburg AA,
Hendriksen PJ. Assessment of the usefulness of the murine cytotoxic T cell line
CTLL-2 for immunotoxicity screening by transcriptomics. Toxicol Lett. 2012 Dec
17. doi:pii: S0378-4274(12)01423-3. 10.1016/j.toxlet.2012.12.005. [Epub ahead of
print] PubMed PMID: 23253260.
2: Theunissen P, Pennings J, van Dartel D, Robinson JF, Kleinjans J, Piersma A.
Complementary detection of embryotoxic properties of substances in the neural and
cardiac embryonic stem cell tests (ESTn and ESTc). Toxicol Sci. 2012 Dec 13.
[Epub ahead of print] PubMed PMID: 23243006.
3: van der Veen JW, Gremmer ER, Vermeulen JP, van Loveren H, Ezendam J. Induction
of skin sensitization is augmented in Nrf2-deficient mice. Arch Toxicol. 2012 Nov
11. [Epub ahead of print] PubMed PMID: 23143620.
4: Pedersen M, von Stedingk H, Botsivali M, Agramunt S, Alexander J, Brunborg G,
Chatzi L, Fleming S, Fthenou E, Granum B, Gutzkow KB, Hardie LJ, Knudsen LE,
Kyrtopoulos SA, Mendez MA, Merlo DF, Nielsen JK, Rydberg P, Segerbäck D, Sunyer
J, Wright J, Törnqvist M, Kleinjans JC, Kogevinas M. Birth Weight, Head
Circumference, and Prenatal Exposure to Acrylamide from Maternal Diet: The
European Prospective Mother-Child Study (NewGeneris). Environ Health Perspect.
2012 Dec;120(12):1739-45. doi: 10.1289/ehp.1205327. Epub 2012 Sep 24. PubMed
PMID: 23092936.
5: van Kesteren PC, Zwart PE, Schaap MM, Pronk TE, van Herwijnen MH, Kleinjans
JC, Bokkers BG, Godschalk RW, Zeilmaker MJ, van Steeg H, Luijten M.
Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in
vivo liver: Toxicokinetics is essential for in vivo-in vitro comparisons. Arch
Toxicol. 2012 Oct 2. [Epub ahead of print] PubMed PMID: 23052197.
6: Doktorova TY, Ellinger-Ziegelbauer H, Vinken M, Vanhaecke T, van Delft J,
Kleinjans J, Ahr HJ, Rogiers V. Comparison of genotoxicant-modified
transcriptomic responses in conventional and epigenetically stabilized primary
rat hepatocytes with in vivo rat liver data. Arch Toxicol. 2012
Nov;86(11):1703-15. doi: 10.1007/s00204-012-0946-8. Epub 2012 Sep 28. PubMed
PMID: 23052194.
7: Stølevik SB, Nygaard UC, Namork E, Haugen M, Meltzer HM, Alexander J, Knutsen
HK, Aaberge I, Vainio K, van Loveren H, Løvik M, Granum B. Prenatal exposure to
polychlorinated biphenyls and dioxins from the maternal diet may be associated
with immunosuppressive effects that persist into early childhood. Food Chem
Toxicol. 2013 Jan;51:165-72. doi: 10.1016/j.fct.2012.09.027. Epub 2012 Oct 2.
PubMed PMID: 23036451.
8: Tonk EC, de Groot DM, Wolterbeek AP, Penninks AH, Waalkens-Berendsen ID,
Piersma AH, van Loveren H. Developmental immunotoxicity of ethanol in an extended
one-generation reproductive toxicity study. Arch Toxicol. 2012 Sep 25. [Epub
ahead of print] PubMed PMID: 23007559.
9: van der Veen JW, Pronk TE, van Loveren H, Ezendam J. Applicability of a
keratinocyte gene signature to predict skin sensitizing potential. Toxicol In
Vitro. 2013 Feb;27(1):314-22. doi: 10.1016/j.tiv.2012.08.023. Epub 2012 Aug 28.
PubMed PMID: 22935770.
10: Tsamou M, Jennen DG, Claessen SM, Magkoufopoulou C, Kleinjans JC, van Delft
JH. Performance of in vitro γH2AX assay in HepG2 cells to predict in vivo
genotoxicity. Mutagenesis. 2012 Nov;27(6):645-52. doi: 10.1093/mutage/ges030.
Epub 2012 Aug 21. PubMed PMID: 22914676.
11: van Delft J, Gaj S, Lienhard M, Albrecht MW, Kirpiy A, Brauers K, Claessen S,
Lizarraga D, Lehrach H, Herwig R, Kleinjans J. RNA-Seq provides new insights in
the transcriptome responses induced by the carcinogen benzo[a]pyrene. Toxicol
Sci. 2012 Dec;130(2):427-39. doi: 10.1093/toxsci/kfs250. Epub 2012 Aug 13. PubMed
PMID: 22889811.
12: Hochstenbach K, van Leeuwen DM, Gmuender H, Gottschalk RW, Løvik M, Granum B,
Nygaard U, Namork E, Kirsch-Volders M, Decordier I, Vande Loock K, Besselink H,
Törnqvist M, von Stedingk H, Rydberg P, Kleinjans JC, van Loveren H, van Delft
JH. Global gene expression analysis in cord blood reveals gender-specific
differences in response to carcinogenic exposure in utero. Cancer Epidemiol
Biomarkers Prev. 2012 Oct;21(10):1756-67. doi: 10.1158/1055-9965.EPI-12-0304.
Epub 2012 Aug 9. PubMed PMID: 22879202.
13: Katika MR, Hendriksen PJ, Shao J, van Loveren H, Peijnenburg A. Transcriptome
analysis of the human T lymphocyte cell line Jurkat and human peripheral blood
mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights.
Toxicol Appl Pharmacol. 2012 Oct 1;264(1):51-64. doi: 10.1016/j.taap.2012.07.017.
Epub 2012 Jul 28. PubMed PMID: 22846391.
14: de Jong HJ, Saldi SR, Klungel OH, Vandebriel RJ, Souverein PC, Meyboom RH,
Passier JL, van Loveren H, Cohen Tervaert JW. Statin-associated polymyalgia
rheumatica. An analysis using WHO global individual case safety database: a
case/non-case approach. PLoS One. 2012;7(7):e41289. doi:
10.1371/journal.pone.0041289. Epub 2012 Jul 23. PubMed PMID: 22844450; PubMed
Central PMCID: PMC3402515.
15: Paglialunga S, van Bree B, Bosma M, Valdecantos MP, Amengual-Cladera E,
Jörgensen JA, van Beurden D, den Hartog GJ, Ouwens DM, Briedé JJ, Schrauwen P,
Hoeks J. Targeting of mitochondrial reactive oxygen species production does not
avert lipid-induced insulin resistance in muscle tissue from mice. Diabetologia.
2012 Oct;55(10):2759-68. doi: 10.1007/s00125-012-2626-x. Epub 2012 Jul 12. PubMed
PMID: 22782287.
16: Limonciel A, Wilmes A, Aschauer L, Radford R, Bloch KM, McMorrow T, Pfaller
W, van Delft JH, Slattery C, Ryan MP, Lock EA, Jennings P. Oxidative stress
induced by potassium bromate exposure results in altered tight junction protein
expression in renal proximal tubule cells. Arch Toxicol. 2012 Nov;86(11):1741-51.
doi: 10.1007/s00204-012-0897-0. Epub 2012 Jul 4. PubMed PMID: 22760423.
17: Hochstenbach K, van Leeuwen DM, Gmuender H, Gottschalk RW, Stølevik SB,
Nygaard UC, Løvik M, Granum B, Namork E, Meltzer HM, Kleinjans JC, van Delft JH,
van Loveren H. Toxicogenomic profiles in relation to maternal immunotoxic
exposure and immune functionality in newborns. Toxicol Sci. 2012
Oct;129(2):315-24. doi: 10.1093/toxsci/kfs214. Epub 2012 Jun 27. PubMed PMID:
22738990; PubMed Central PMCID: PMC3529642.
18: Laubenthal J, Zlobinskaya O, Poterlowicz K, Baumgartner A, Gdula MR, Fthenou
E, Keramarou M, Hepworth SJ, Kleinjans JC, van Schooten FJ, Brunborg G, Godschalk
RW, Schmid TE, Anderson D. Cigarette smoke-induced transgenerational alterations
in genome stability in cord blood of human F1 offspring. FASEB J. 2012
Oct;26(10):3946-56. doi: 10.1096/fj.11-201194. Epub 2012 Jun 22. PubMed PMID:
22730438.
19: de Jong HJ, Vandebriel RJ, Saldi SR, van Dijk L, van Loveren H, Cohen
Tervaert JW, Klungel OH. Angiotensin-converting enzyme inhibitors or angiotensin
II receptor blockers and the risk of developing rheumatoid arthritis in
antihypertensive drug users. Pharmacoepidemiol Drug Saf. 2012 Aug;21(8):835-43.
doi: 10.1002/pds.3291. Epub 2012 Jun 6. PubMed PMID: 22674737.
20: Wijnands KA, Vink H, Briedé JJ, van Faassen EE, Lamers WH, Buurman WA, Poeze
M. Citrulline a more suitable substrate than arginine to restore NO production
and the microcirculation during endotoxemia. PLoS One. 2012;7(5):e37439. doi:
10.1371/journal.pone.0037439. Epub 2012 May 29. PubMed PMID: 22666356; PubMed
Central PMCID: PMC3362574.
21: Theunissen PT, Robinson JF, Pennings JL, van Herwijnen MH, Kleinjans JC,
Piersma AH. Compound-specific effects of diverse neurodevelopmental toxicants on
global gene expression in the neural embryonic stem cell test (ESTn). Toxicol
Appl Pharmacol. 2012 Aug 1;262(3):330-40. doi: 10.1016/j.taap.2012.05.011. Epub
2012 May 23. PubMed PMID: 22634333.
22: Magkoufopoulou C, Claessen SM, Tsamou M, Jennen DG, Kleinjans JC, van Delft
JH. A transcriptomics-based in vitro assay for predicting chemical genotoxicity
in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9. doi: 10.1093/carcin/bgs182. Epub
2012 May 23. PubMed PMID: 22623647.
23: Katika MR, Hendriksen PJ, de Ruijter NC, van Loveren H, Peijnenburg A.
Immunocytological and biochemical analysis of the mode of action of bis
(tri-n-butyltin) tri-oxide (TBTO) in Jurkat cells. Toxicol Lett. 2012 Jul
20;212(2):126-36. doi: 10.1016/j.toxlet.2012.05.010. Epub 2012 May 18. PubMed
PMID: 22613032.
24: Piersma AH, Tonk EC, Makris SL, Crofton KM, Dietert RR, van Loveren H.
Juvenile toxicity testing protocols for chemicals. Reprod Toxicol. 2012
Nov;34(3):482-6. doi: 10.1016/j.reprotox.2012.04.010. Epub 2012 May 4. PubMed
PMID: 22564981.
25: Ezendam J, Vermeulen JP, de Klerk A, de Jong WH, van Loveren H. A
quantitative approach to assess the potency of skin sensitizers in the
elicitation phase. Toxicology. 2012 Sep 4;299(1):20-4. doi:
10.1016/j.tox.2012.05.002. Epub 2012 May 4. PubMed PMID: 22564262.
26: Vandebriel RJ, De Jong HJ, Gremmer ER, Klungel OH, Tervaert JW, Slob W, Van
Der Laan JW, Van Loveren H. Statins accelerate the onset of collagen type
II-induced arthritis in mice. Arthritis Res Ther. 2012 Apr 26;14(2):R90. doi:
10.1186/ar3814. PubMed PMID: 22537858; PubMed Central PMCID: PMC3446464.
27: van Ravenzwaay B, Brunborg G, Kleinjans J. Conclusions and outlook. Mutat
Res. 2012 Aug 15;746(2):171-2. doi: 10.1016/j.mrgentox.2012.04.005. Epub 2012 Apr
16. PubMed PMID: 22531766.
28: van Ravenzwaay B, Brunborg G, Kleinjans J, Galay Burgos M, Vrijhof H. Use of
'omics to elucidate mechanism of action and integration of 'omics in a systems
biology concept. Mutat Res. 2012 Aug 15;746(2):95-6. doi:
10.1016/j.mrgentox.2012.04.004. Epub 2012 Apr 13. PubMed PMID: 22525362.
29: Doktorova TY, Ellinger-Ziegelbauer H, Vinken M, Vanhaecke T, van Delft J,
Kleinjans J, Ahr HJ, Rogiers V. Comparison of hepatocarcinogen-induced gene
expression profiles in conventional primary rat hepatocytes with in vivo rat
liver. Arch Toxicol. 2012 Sep;86(9):1399-411. doi: 10.1007/s00204-012-0847-x.
Epub 2012 Apr 8. PubMed PMID: 22484513.
30: van Kol SW, Hendriksen PJ, van Loveren H, Peijnenburg A. Transcriptomics
analysis of primary mouse thymocytes exposed to bis(tri-n-butyltin)dioxide
(TBTO). Toxicology. 2012 Jun 14;296(1-3):37-47. doi: 10.1016/j.tox.2012.03.002.
Epub 2012 Mar 14. PubMed PMID: 22434021.
31: Lizarraga D, Gaj S, Brauers KJ, Timmermans L, Kleinjans JC, van Delft JH.
Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012
Apr 16;25(4):838-49. doi: 10.1021/tx2003799. Epub 2012 Feb 22. PubMed PMID:
22316170.
32: Tonk EC, Verhoef A, Gremmer ER, van Loveren H, Piersma AH. Relative
sensitivity of developmental and immune parameters in juvenile versus adult male
rats after exposure to di(2-ethylhexyl) phthalate. Toxicol Appl Pharmacol. 2012
Apr 1;260(1):48-57. doi: 10.1016/j.taap.2012.01.018. Epub 2012 Jan 31. PubMed
PMID: 22310177.
33: Jetten MJ, Gaj S, Ruiz-Aracama A, de Kok TM, van Delft JH, Lommen A, van
Someren EP, Jennen DG, Claessen SM, Peijnenburg AA, Stierum RH, Kleinjans JC.
'Omics analysis of low dose acetaminophen intake demonstrates novel response
pathways in humans. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):320-8. doi:
10.1016/j.taap.2012.01.009. Epub 2012 Jan 20. PubMed PMID: 22285215.
34: Sansone SA, Rocca-Serra P, Field D, Maguire E, Taylor C, Hofmann O, Fang H,
Neumann S, Tong W, Amaral-Zettler L, Begley K, Booth T, Bougueleret L, Burns G,
Chapman B, Clark T, Coleman LA, Copeland J, Das S, de Daruvar A, de Matos P, Dix
I, Edmunds S, Evelo CT, Forster MJ, Gaudet P, Gilbert J, Goble C, Griffin JL,
Jacob D, Kleinjans J, Harland L, Haug K, Hermjakob H, Ho Sui SJ, Laederach A,
Liang S, Marshall S, McGrath A, Merrill E, Reilly D, Roux M, Shamu CE, Shang CA,
Steinbeck C, Trefethen A, Williams-Jones B, Wolstencroft K, Xenarios I, Hide W.
Toward interoperable bioscience data. Nat Genet. 2012 Jan 27;44(2):121-6. doi:
10.1038/ng.1054. PubMed PMID: 22281772; PubMed Central PMCID: PMC3428019.
35: Van Summeren A, Renes J, van Delft JH, Kleinjans JC, Mariman EC. Proteomics
in the search for mechanisms and biomarkers of drug-induced hepatotoxicity.
Toxicol In Vitro. 2012 Apr;26(3):373-85. doi: 10.1016/j.tiv.2012.01.012. Epub
2012 Jan 17. Review. PubMed PMID: 22274661.
36: Hochstenbach K, van Leeuwen DM, Gottschalk RW, Gmuender H, Stølevik SB,
Nygaard UC, Løvik M, Granum B, Namork E, van Loveren H, van Delft JH.
Transcriptomic fingerprints in human peripheral blood mononuclear cells
indicative of genotoxic and non-genotoxic carcinogenic exposure. Mutat Res. 2012
Aug 15;746(2):124-34. doi: 10.1016/j.mrgentox.2012.01.002. Epub 2012 Jan 16.
PubMed PMID: 22269147.
37: Radford R, Slattery C, Jennings P, Blaque O, Pfaller W, Gmuender H, Van Delft
J, Ryan MP, McMorrow T. Carcinogens induce loss of the primary cilium in human
renal proximal tubular epithelial cells independently of effects on the cell
cycle. Am J Physiol Renal Physiol. 2012 Apr 15;302(8):F905-16. doi:
10.1152/ajprenal.00427.2011. Epub 2012 Jan 18. PubMed PMID: 22262483.
38: van Loveren H, Sanz Y, Salminen S. Health claims in Europe: probiotics and
prebiotics as case examples. Annu Rev Food Sci Technol. 2012;3:247-61. doi:
10.1146/annurev-food-022811-101206. Epub 2012 Jan 3. Review. PubMed PMID:
22224554.
39: Osman AM, van Loveren H. Phosphoproteomic analysis of mouse thymoma cells
treated with tributyltin oxide: TBTO affects proliferation and energy sensing
pathways. Toxicol Sci. 2012 Mar;126(1):84-100. doi: 10.1093/toxsci/kfr333. Epub
2011 Dec 15. PubMed PMID: 22174045.
40: Theunissen PT, Robinson JF, Pennings JL, de Jong E, Claessen SM, Kleinjans
JC, Piersma AH. Transcriptomic concentration-response evaluation of valproic
acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test
(ESTn). Toxicol Sci. 2012 Feb;125(2):430-8. doi: 10.1093/toxsci/kfr293. Epub 2011
Nov 1. PubMed PMID: 22045034.
41: Hebels DG, Sveje KM, de Kok MC, van Herwijnen MH, Kuhnle GG, Engels LG,
Vleugels-Simon CB, Mares WG, Pierik M, Masclee AA, Kleinjans JC, de Kok TM. Red
meat intake-induced increases in fecal water genotoxicity correlate with
pro-carcinogenic gene expression changes in the human colon. Food Chem Toxicol.
2012 Feb;50(2):95-103. doi: 10.1016/j.fct.2011.10.038. Epub 2011 Oct 14. PubMed
PMID: 22019696.
42: Cramers P, Filon AR, Pines A, Kleinjans JC, Mullenders LH, van Zeeland AA.
Enhanced nucleotide excision repair in human fibroblasts pre-exposed to ionizing
radiation. Photochem Photobiol. 2012 Jan-Feb;88(1):147-53. doi:
10.1111/j.1751-1097.2011.01019.x. Epub 2011 Nov 17. PubMed PMID: 22017241.
43: de Jong HJ, Klungel OH, van Dijk L, Vandebriel RJ, Leufkens HG, van der Laan
JW, Cohen Tervaert JW, van Loveren H. Use of statins is associated with an
increased risk of rheumatoid arthritis. Ann Rheum Dis. 2012 May;71(5):648-54.
doi: 10.1136/ard.2011.155622. Epub 2011 Oct 6. PubMed PMID: 21979000.
44: Kok TM, Breda SG, Briedé JJ. Genomics-based identification of molecular
mechanisms behind the cancer preventive action of phytochemicals: potential and
challenges. Curr Pharm Biotechnol. 2012 Jan;13(1):255-64. Review. PubMed PMID:
21466423.