Department of Toxicogenomics

2011

  1. Osman AM, van Loveren H. Phosphoproteomic analysis of mouse thymoma cells treated with tributyltin oxide: TBTO affects proliferation and energy sensing pathways. Toxicol Sci. 2012 Mar;126(1):84-100. doi: 10.1093/toxsci/kfr333. Epub 2011 Dec 15. PubMed PMID: 22174045.
  2. Nabben M, Hoeks J, Moonen-Kornips E, van Beurden D, Briedé JJ, Hesselink MK, Glatz JF, Schrauwen P. Significance of uncoupling protein 3 in mitochondrial function upon mid- and long-term dietary high-fat exposure. FEBS Lett. 2011 Dec 15;585(24):4010-7. doi: 10.1016/j.febslet. 2011.11.012. Epub 2011 Nov 21. PubMed PMID: 22115550.
  3. Theunissen PT, Robinson JF, Pennings JL, de Jong E, Claessen SM, Kleinjans JC, Piersma AH. Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn). Toxicol Sci. 2012 Feb;125(2):430-8. doi: 10.1093/toxsci/kfr293. Epub 2011 Nov 1. PubMed PMID: 22045034.
  4. Hebels DG, Sveje KM, de Kok MC, van Herwijnen MH, Kuhnle GG, Engels LG, Vleugels-Simon CB, Mares WG, Pierik M, Masclee AA, Kleinjans JC, de Kok TM. Red meat intake-induced increases in fecal water genotoxicity correlate with pro-carcinogenic gene expression changes in the human colon. Food Chem Toxicol. 2012 Feb;50(2):95-103. doi: 10.1016/ j.fct.2011.10.038. Epub 2011 Oct 14. PubMed PMID: 22019696.
  5. Cramers P, Filon AR, Pines A, Kleinjans JC, Mullenders LH, van Zeeland AA. Enhanced nucleotide excision repair in human fibroblasts pre-exposed to ionizing radiation. Photochem Photobiol. 2012 Jan-Feb;88(1):147-53. doi: 10.1111/j.1751-1097.2011.01019.x. Epub 2011 Nov 17. PubMed PMID: 22017241.
  6. de Jong HJ, Klungel OH, van Dijk L, Vandebriel RJ, Leufkens HG, van der Laan JW, Cohen Tervaert JW, van Loveren H. Use of statins is associated with an increased risk of rheumatoid arthritis. Ann Rheum Dis. 2012 May;71(5):648-54. doi: 10.1136/ard.2011.155622. Epub 2011 Oct 6. PubMed PMID: 21979000.
  7. Ketelslegers HB, Godschalk RW, Gottschalk RW, Knaapen AM, Koppen G, Schoeters G, Baeyens WF, Nelen V, Geraedts JP, van Delft JH, Kleinjans JC, van Larebeke NA. Prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in Flanders: a cross sectional study. Environ Health. 2011 Oct 5;10:85. doi: 10.1186/1476-069X-10-85. PubMed PMID: 21975123; PubMed Central PMCID: PMC3195704.
  8. Hebels DG, Brauers KJ, van Herwijnen MH, Georgiadis PA, Kyrtopoulos SA, Kleinjans JC, de Kok TM. Time-series analysis of gene expression profiles induced by nitrosamides and nitrosamines elucidates modes of action underlying their genotoxicity in human colon cells. Toxicol Lett. 2011 Dec 15;207(3):232-41. doi: 10.1016/j.toxlet.2011.09.012. Epub 2011 Sep 19. PubMed PMID: 21946166.
  9. Park MV, Neigh AM, Vermeulen JP, de la Fonteyne LJ, Verharen HW, Briedé JJ, van Loveren H, de Jong WH. The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles. Biomaterials. 2011 Dec;32(36):9810-7. doi: 10.1016/ j.biomaterials.2011.08.085. Epub 2011 Sep 25. PubMed PMID: 21944826.
  10. Tonk EC, Verhoef A, de la Fonteyne LJ, Waalkens-Berendsen ID, Wolterbeek AP, van Loveren H, Piersma AH. Developmental immunotoxicity in male rats after juvenile exposure to di-n-octyltin dichloride (DOTC). Reprod Toxicol. 2011 Nov;32(3):341-8. doi: 10.1016/j.reprotox.2011.08.005. Epub 2011 Sep 10. PubMed PMID: 21925263.
  11. Jennen D, Ruiz-Aracama A, Magkoufopoulou C, Peijnenburg A, Lommen A, van Delft J, Kleinjans J. Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells. BMC Syst Biol. 2011 Aug 31;5:139. doi: 10.1186/1752-0509-5-139. PubMed PMID: 21880148; PubMed Central PMCID: PMC3231768.
  12. Yildirimman R, Brolén G, Vilardell M, Eriksson G, Synnergren J, Gmuender H, Kamburov A, Ingelman-Sundberg M, Castell J, Lahoz A, Kleinjans J, van Delft J, Björquist P, Herwig R. Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27. PubMed PMID: 21873647; PubMed Central PMCID: PMC3216410.
  13. de Jong HJ, Tervaert JW, Saldi SR, Vandebriel RJ, Souverein PC, Meyboom RH, van Loveren H, Klungel OH. Association between statin use and lupus-like syndrome using spontaneous reports. Semin Arthritis Rheum. 2011 Dec;41(3):373-81. doi: 10.1016/j.semarthrit.2011.06.002. Epub 2011 Aug 24. PubMed PMID: 21868063.
  14. Eussen SR, Verhagen H, Klungel OH, Garssen J, van Loveren H, van Kranen HJ, Rompelberg CJ. Functional foods and dietary supplements: products at the interface between pharma and nutrition. Eur J Pharmacol. 2011 Sep;668 Suppl 1:S2-9. doi: 10.1016/j.ejphar.2011.07.008. Epub 2011 Jul 27. Review. PubMed PMID: 21816140.
  15. Lizarraga D, Vinardell MP, Noé V, van Delft JH, Alcarraz-Vizán G, van Breda SG, Staal Y, Günther UL, Carrigan JB, Reed MA, Ciudad CJ, Torres JL, Cascante M. A lyophilized red grape pomace containing proanthocyanidin-rich dietary fiber induces genetic and metabolic alterations in colon mucosa of female C57BL/6J mice. J Nutr. 2011 Sep;141(9):1597-604. doi: 10.3945/jn.110.133199. Epub 2011 Jul 20. Erratum in: J Nutr. 2012 Feb 1;142(2):396. Carrigan, John B [added]. PubMed PMID: 21775529.
  16. Hebels DG, Jennen DG, van Herwijnen MH, Moonen EJ, Pedersen M, Knudsen LE, Kleinjans JC, de Kok TM. Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells. Mutagenesis. 2011 Nov;26(6):753-61. doi: 10.1093/mutage/ger043. Epub 2011 Jul 1. PubMed PMID: 21724973.
  17. van Kesteren PC, Zwart PE, Pennings JL, Gottschalk WH, Kleinjans JC, van Delft JH, van Steeg H, Luijten M. Deregulation of cancer-related pathways in primary hepatocytes derived from DNA repair-deficient Xpa-/-p53+/- mice upon exposure to benzo[a]pyrene. Toxicol Sci. 2011 Sep;123 (1):123-32. doi: 10.1093/toxsci/kfr169. Epub 2011 Jun 29. PubMed PMID: 21715664.
  18. Hebels DG, Sveje KM, de Kok MC, van Herwijnen MH, Kuhnle GG, Engels LG, Vleugels-Simon CB, Mares WG, Pierik M, Masclee AA, Kleinjans JC, de Kok TM. N-nitroso compound exposure-associated transcriptomic profiles are indicative of  an increased risk for colorectal cancer. Cancer Lett. 2011 Oct 1;309(1):1-10. doi: 10.1016/j.canlet. 2011.05.007. Epub 2011 Jun 12. PubMed PMID: 21669488.
  19. Magkoufopoulou C, Claessen SM, Jennen DG, Kleinjans JC, van Delft JH. Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604. doi: 10.1093/mutage/ger021. Epub 2011 Jun 1. PubMed PMID: 21632981.
  20. Vande Loock K, Fthenou E, Decordier I, Chalkiadaki G, Keramarou M, Plas G, Roelants M, Kleinjans J, Chatzi L, Merlo F, Kogevinas M, Kirsch-Volders M. Maternal and gestational factors and micronucleus frequencies in umbilical blood: the NewGeneris Rhea cohort in Crete. Environ Health Perspect. 2011 Oct;119(10):1460-5. doi: 10.1289/ehp.1003246. Epub 2011 May 27. PubMed PMID: 21622084; PubMed Central PMCID: PMC3230441.
  21. Linschooten JO, Laubenthal J, Cemeli E, Baumgartner A, Anderson D, Sipinen VE, Brunborg G, Haenen GR, Fthenou E, Briedé JJ, van Schooten FJ, Godschalk RW. Incomplete protection of genetic integrity of mature spermatozoa against oxidative stress. Reprod Toxicol. 2011 Jul;32(1):106-11. doi: 10.1016/j.reprotox.2011.05.004. Epub 2011 May 20. PubMed PMID: 21621604.
  22. Pronk TE, van der Veen JW, Ezendam J, Van Loveren H, Pennings JL. Effects of pooling RNA from samples treated with different compounds for determining class specific biomarkers and processes in toxicogenomics. Toxicol In Vitro. 2011 Dec;25(8):1841-7. doi: 10.1016/j.tiv.2011.05.012. Epub 2011 May 19. PubMed PMID: 21620947.
  23. Theunissen PT, Pennings JL, Robinson JF, Claessen SM, Kleinjans JC, Piersma AH. Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells. Toxicol Sci. 2011 Aug;122(2):437-47. doi: 10.1093/toxsci/kfr134. Epub 2011 May 25. PubMed PMID: 21613230.
  24. Katika MR, Hendriksen PJ, van Loveren H, Peijnenburg A. Exposure of Jurkat cells to bis (tri-n-butyltin) oxide (TBTO) induces transcriptomics changes indicative for ER- and oxidative stress, T cell activation and apoptosis. Toxicol Appl Pharmacol. 2011 Aug 1;254(3):311-22. doi: 10.1016/j.taap.2011.04.021. Epub 2011 May 13. PubMed PMID: 21601586.
  25. Ruiz-Aracama A, Peijnenburg A, Kleinjans J, Jennen D, van Delft J, Hellfrisch C, Lommen A. An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. BMC Genomics. 2011 May 20;12:251. doi: 10.1186/1471-2164-12-251. PubMed PMID: 21599895; PubMed Central PMCID: PMC3141663.
  26. Stølevik SB, Nygaard UC, Namork E, Haugen M, Kvalem HE, Meltzer HM, Alexander J, van Delft JH, Loveren Hv, Løvik M, Granum B. Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants. Food Chem Toxicol. 2011 Aug;49(8):1843-8. doi: 10.1016/j.fct.2011.05.002. Epub 2011 May 6. PubMed PMID: 21571030.
  27. Vandebriel R, Callant Cransveld C, Crommelin D, Diamant Z, Glazenburg B, Joos G, Kuper F, Natsch A, Nijkamp F, Noteborn H, Pieters R, Roberts D, Roggen E, Rorije E, Seed M, Sewald K, van den Heuvel R, van Engelen J, Verstraelen S, van Loveren H. Respiratory sensitization: advances in assessing the risk of respiratory inflammation and irritation. Toxicol In Vitro. 2011 Oct;25(7):1251-8. doi: 10.1016/j.tiv.2011.04.027. Epub 2011 May 5. Review. PubMed PMID: 21570460.
  28. Tonk EC, de Groot DM, Penninks AH, Waalkens-Berendsen ID, Wolterbeek AP, Piersma AH, van Loveren H. Developmental immunotoxicity of di-n-octyltin dichloride (DOTC) in an extended one-generation reproductive toxicity study. Toxicol Lett. 2011 Jul 28;204(2-3):156-63. doi: 10.1016/j.toxlet.2011.04.027. Epub 2011 Apr 30. PubMed PMID: 21557992.
  29. Adler S, Basketter D, Creton S, Pelkonen O, van Benthem J, Zuang V, Andersen KE, Angers-Loustau A, Aptula A, Bal-Price A, Benfenati E, Bernauer U, Bessems J, Bois FY, Boobis A, Brandon E, Bremer S, Broschard T, Casati S, Coecke S, Corvi R, Cronin M, Daston G, Dekant W, Felter S, Grignard E, Gundert-Remy U, Heinonen T, Kimber I, Kleinjans J, Komulainen H, Kreiling R, Kreysa J, Leite SB, Loizou G, Maxwell G, Mazzatorta P, Munn S, Pfuhler S, Phrakonkham P, Piersma A, Poth A, Prieto P, Repetto G, Rogiers V, Schoeters G, Schwarz M, Serafimova R, Tähti H, Testai E, van Delft J, van Loveren H, Vinken M, Worth A, Zaldivar JM. Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010. Arch Toxicol. 2011 May;85(5): 367-485. doi: 10.1007/s00204-011-0693-2. Epub 2011 May 1. Review. PubMed PMID: 21533817.
  30. Bolleyn J, Fraczek J, Vinken M, Lizarraga D, Gaj S, van Delft JH, Rogiers V, Vanhaecke T. Effect of Trichostatin A on miRNA expression in cultures of primary rat hepatocytes. Toxicol In Vitro. 2011 Sep;25(6):1173-82. doi: 10.1016/j.tiv.2011.04.013. Epub 2011 Apr 13. PubMed PMID: 21513791.
  31. Cramers P, Verhoeven EE, Filon AR, Rockx DA, Santos SJ, van der Leer AA, Kleinjans JC, van Zeeland AA, Mullenders LH. Impaired repair of ionizing radiation-induced DNA damage in Cockayne syndrome cells. Radiat Res. 2011 Apr;175(4):432-43. doi: 10.1667/RR1972.1. Epub 2011 Feb 7. PubMed PMID: 21299404.
  32. Danielsen PH, Møller P, Jensen KA, Sharma AK, Wallin H, Bossi R, Autrup H, Mølhave L, Ravanat JL, Briedé JJ, de Kok TM, Loft S. Oxidative stress, DNA damage, and inflammation induced by ambient air and wood smoke particulate matter in human A549 and THP-1 cell lines. Chem Res Toxicol. 2011 Feb 18;24(2):168-84. doi: 10.1021/tx100407m. Epub 2011 Jan 14. PubMed PMID: 21235221.
  33. van Dartel DA, Pennings JL, Robinson JF, Kleinjans JC, Piersma AH. Discriminating classes of developmental toxicants using gene expression profiling in the embryonic stem cell test. Toxicol Lett. 2011 Mar 5;201 (2):143-51. doi: 10.1016/j.toxlet.2010.12.019. Epub 2010 Dec 30. PubMed PMID: 21195148.
  34. van Dartel DA, Pennings JL, de la Fonteyne LJ, Brauers KJ, Claessen S, van Delft JH, Kleinjans JC, Piersma AH. Concentration-dependent gene expression responses to flusilazole in embryonic stem cell differentiation cultures. Toxicol Appl Pharmacol. 2011 Mar 1;251(2):110-8. doi: 10.1016/ .taap.2010.12.008. Epub 2010 Dec 28. PubMed PMID: 21192963.
  35. van Leeuwen DM, Pedersen M, Knudsen LE, Bonassi S, Fenech M, Kleinjans JC, Jennen DG. Transcriptomic network analysis of micronuclei-related genes: a case study. Mutagenesis. 2011 Jan;26(1):27-32. doi: 10.1093/mutage/geq074. Review. PubMed PMID: 21164179.
  36. Van Summeren A, Renes J, Bouwman FG, Noben JP, van Delft JH, Kleinjans JC, Mariman EC. Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22. doi: 10.1093/toxsci/kfq380. Epub 2010 Dec 16. PubMed PMID: 21163907.
  37. Paules RS, Aubrecht J, Corvi R, Garthoff B, Kleinjans JC. Moving forward in human cancer risk assessment. Environ Health Perspect. 2011 Jun;119 6):739-43. doi: 10.1289/ehp.1002735. Epub 2010 Dec 13. PubMed PMID: 21147607; PubMed Central PMCID: PMC3114805.
  38. Stølevik SB, Nygaard UC, Namork E, Granum B, Pellerud A, van Leeuwen DM, Gmuender H, van Delft JH, van Loveren H, Løvik M. In vitro cytokine release from human peripheral blood mononuclear cells in the assessment of the immunotoxic potential of chemicals. Toxicol In Vitro. 2011 Mar;25(2) 555-62. doi: 10.1016/j.tiv.2010.11.021. Epub 2010 Dec 7. PubMed PMID: 21144890.
  39. van Kol SW, Hendriksen PJ, van Loveren H, Peijnenburg A. The effects of deoxynivalenol on gene expression in the murine thymus. Toxicol Appl Pharmacol. 2011 Feb 1;250(3):299-311. doi: 10.1016/j.taap.2010.11.001. Epub 2010 Nov 11. PubMed PMID: 21074547.
  40. Kienhuis AS, Bessems JG, Pennings JL, Driessen M, Luijten M, van Delft JH, Peijnenburg AA, van der Ven LT. Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study. Toxicol Appl Pharmacol. 2011 Jan 15;250(2):96-107. doi: 10.1016/ .taap.2010.10.013. Epub 2010 Oct 21. Review. PubMed PMID: 20970440.
  41. van Dartel DA, Pennings JL, de la Fonteyne LJ, Brauers KJ, Claessen S, van Delft JH, Kleinjans JC, Piersma AH. Evaluation of developmental toxicant identification using gene expression profiling in embryonic stem cell differentiation cultures. Toxicol Sci. 2011 Jan;119(1):126-34. doi: 10.1093/toxsci/kfq291. Epub 2010 Oct 8. PubMed PMID: 20935163.