Department of Toxicogenomics

2012

  1. Schmeits PC, Volger OL, Zandvliet ET, van Loveren H, Peijnenburg AA, Hendriksen PJ. Assessment of the usefulness of the murine cytotoxic T cell line CTLL-2 for immunotoxicity screening by transcriptomics. Toxicol Lett. 2012 Dec 17. doi:pii: S0378-4274(12)01423-3. 10.1016/j.toxlet.2012. 12.005. PubMed PMID: 23253260.
  2. Theunissen P, Pennings J, van Dartel D, Robinson JF, Kleinjans J, Piersma A. Complementary detection of embryotoxic properties of substances in the neural and cardiac embryonic stem cell tests (ESTn and ESTc). Toxicol Sci. 2012 Dec 13. PubMed PMID: 23243006.
  3. van der Veen JW, Gremmer ER, Vermeulen JP, van Loveren H, Ezendam J. Induction of skin sensitization is augmented in Nrf2-deficient mice. Arch Toxicol. 2012 Nov 11. PubMed PMID: 23143620.
  4. Pedersen M, von Stedingk H, Botsivali M, Agramunt S, Alexander J, Brunborg G, Chatzi L, Fleming S, Fthenou E, Granum B, Gutzkow KB, Hardie LJ, Knudsen LE, Kyrtopoulos SA, Mendez MA, Merlo DF, Nielsen JK, Rydberg P, Segerbäck D, Sunyer J, Wright J, Törnqvist M, Kleinjans JC, Kogevinas M. Birth Weight, Head Circumference, and Prenatal Exposure to Acrylamide from Maternal Diet: The European Prospective Mother-Child Study (NewGeneris). Environ Health Perspect. 2012 Dec;120(12):1739-45. doi: 10.1289/ehp.1205327. Epub 2012 Sep 24. PubMed PMID: 23092936.
  5. van Kesteren PC, Zwart PE, Schaap MM, Pronk TE, van Herwijnen MH, Kleinjans JC, Bokkers BG, Godschalk RW, Zeilmaker MJ, van Steeg H, Luijten M. Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: Toxicokinetics is essential for in vivo-in vitro comparisons. Arch Toxicol. 2012 Oct 2. PubMed PMID: 23052197.
  6. Doktorova TY, Ellinger-Ziegelbauer H, Vinken M, Vanhaecke T, van Delft J, Kleinjans J, Ahr HJ, Rogiers V. Comparison of genotoxicant-modified transcriptomic responses in conventional and epigenetically stabilized primary rat hepatocytes with in vivo rat liver data. Arch Toxicol. 2012 Nov;86(11): 1703-15. doi: 10.1007/s00204-012-0946-8. Epub 2012 Sep 28. PubMed PMID: 23052194.
  7. Stølevik SB, Nygaard UC, Namork E, Haugen M, Meltzer HM, Alexander J, Knutsen HK, Aaberge I, Vainio K, van Loveren H, Løvik M, Granum B. Prenatal exposure to polychlorinated biphenyls and dioxins from the maternal diet may be associated with immunosuppressive effects that persist into early childhood. Food Chem Toxicol. 2013 Jan;51:165-72. doi: 10.1016/j.fct.2012.09.027. Epub 2012 Oct 2. PubMed PMID: 23036451.
  8. Tonk EC, de Groot DM, Wolterbeek AP, Penninks AH, Waalkens-Berendsen ID, Piersma AH, van Loveren H. Developmental immunotoxicity of ethanol in an extended one-generation reproductive toxicity study. Arch Toxicol. 2012 Sep 25. PubMed PMID: 23007559.
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  10. van der Veen JW, Pronk TE, van Loveren H, Ezendam J. Applicability of a keratinocyte gene signature to predict skin sensitizing potential. Toxicol In Vitro. 2013 Feb;27(1):314-22. doi: 10.1016/j.tiv.2012. 08.023. Epub 2012 Aug 28. PubMed PMID: 22935770.
  11. Tsamou M, Jennen DG, Claessen SM, Magkoufopoulou C, Kleinjans JC, van Delft JH. Performance of in vitro γH2AX assay in HepG2 cells to predict in vivo genotoxicity. Mutagenesis. 2012 Nov;27(6):645-52. doi: 10.1093/mutage/ges030. Epub 2012 Aug 21. PubMed PMID: 22914676.
  12. van Delft J, Gaj S, Lienhard M, Albrecht MW, Kirpiy A, Brauers K, Claessen S, Lizarraga D, Lehrach H, Herwig R, Kleinjans J. RNA-Seq provides new insights in the transcriptome responses induced by the carcinogen benzo[a]pyrene. Toxicol Sci. 2012 Dec;130(2):427-39. doi: 10.1093/toxsci/kfs250. Epub 2012 Aug 13. PubMed PMID: 22889811.
  13. Hochstenbach K, van Leeuwen DM, Gmuender H, Gottschalk RW, Løvik M, Granum B, Nygaard U, Namork E, Kirsch-Volders M, Decordier I, Vande Loock K, Besselink H, Törnqvist M, von Stedingk H, Rydberg P, Kleinjans JC, van Loveren H, van Delft JH. Global gene expression analysis in cord blood reveals gender-specific differences in response to carcinogenic exposure in utero. Cancer Epidemiol Biomarkers Prev. 2012 Oct;21(10):1756-67. doi: 10.1158/1055-9965.EPI-12-0304.Epub 2012 Aug 9. PubMed PMID: 22879202.
  14. Katika MR, Hendriksen PJ, Shao J, van Loveren H, Peijnenburg A. Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights. Toxicol Appl Pharmacol. 2012 Oct 1;264(1):51-64. doi: 10.1016/j.taap.2012.07.017. Epub 2012 Jul 28. PubMed PMID: 22846391.
  15. de Jong HJ, Saldi SR, Klungel OH, Vandebriel RJ, Souverein PC, Meyboom RH, Passier JL, van Loveren H, Cohen Tervaert JW. Statin-associated polymyalgia rheumatica. An analysis using WHO global individual case safety database: a case/non-case approach. PLoS One. 2012;7(7):e41289. doi: 10.1371/journal.pone.0041289. Epub 2012 Jul 23. PubMed PMID: 22844450; PubMed Central PMCID: PMC3402515.
  16. Paglialunga S, van Bree B, Bosma M, Valdecantos MP, Amengual-Cladera E, Jörgensen JA, van Beurden D, den Hartog GJ, Ouwens DM, Briedé JJ, Schrauwen P, Hoeks J. Targeting of mitochondrial reactive oxygen species production does not avert lipid-induced insulin resistance in muscle tissue from mice. Diabetologia. 2012 Oct;55(10):2759-68. doi: 10.1007/s00125-012-2626-x. Epub 2012 Jul 12. PubMed PMID: 22782287.
  17. Limonciel A, Wilmes A, Aschauer L, Radford R, Bloch KM, McMorrow T, Pfaller W, van Delft JH, Slattery C, Ryan MP, Lock EA, Jennings P. Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells. Arch Toxicol. 2012 Nov;86(11):1741-51. doi: 10.1007/s00204-012-0897-0. Epub 2012 Jul 4. PubMed PMID: 22760423.
  18. Hochstenbach K, van Leeuwen DM, Gmuender H, Gottschalk RW, Stølevik SB, Nygaard UC, Løvik M, Granum B, Namork E, Meltzer HM, Kleinjans JC, van Delft JH, van Loveren H. Toxicogenomic profiles in relation to maternal immunotoxic exposure and immune functionality in newborns. Toxicol Sci. 2012 Oct;129(2):315-24. doi: 10.1093/toxsci/kfs214. Epub 2012 Jun 27. PubMed PMID: 22738990; PubMed Central PMCID: PMC3529642.
  19. Laubenthal J, Zlobinskaya O, Poterlowicz K, Baumgartner A, Gdula MR, Fthenou E, Keramarou M, Hepworth SJ, Kleinjans JC, van Schooten FJ, Brunborg G, Godschalk RW, Schmid TE, Anderson D. Cigarette smoke-induced transgenerational alterations in genome stability in cord blood of human F1 offspring. FASEB J. 2012 Oct;26(10):3946-56. doi: 10.1096/ fj.11-201194. Epub 2012 Jun 22. PubMed PMID: 22730438.
  20. de Jong HJ, Vandebriel RJ, Saldi SR, van Dijk L, van Loveren H, Cohen Tervaert JW, Klungel OH. Angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers and the risk of developing rheumatoid arthritis in antihypertensive drug users. Pharmacoepidemiol Drug Saf. 2012 Aug;21(8):835-43. doi: 10.1002/pds.3291. Epub 2012 Jun 6. PubMed PMID: 22674737.
  21. Wijnands KA, Vink H, Briedé JJ, van Faassen EE, Lamers WH, Buurman WA, Poeze M. Citrulline a more suitable substrate than arginine to restore NO production and the microcirculation during endotoxemia. PLoS One. 2012;7(5):e37439. doi: 10.1371/journal.pone.0037439. Epub 2012 May 29. PubMed PMID: 22666356; PubMed Central PMCID: PMC3362574.
  22. Theunissen PT, Robinson JF, Pennings JL, van Herwijnen MH, Kleinjans JC, Piersma AH. Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn). Toxicol Appl Pharmacol. 2012 Aug 1;262(3):330-40. doi: 10.1016/j.taap.2012.05.011. Epub 2012 May 23. PubMed PMID: 22634333.
  23. Magkoufopoulou C, Claessen SM, Tsamou M, Jennen DG, Kleinjans JC, van Delft JH. A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9. doi:10.1093/ carcin/bgs182. Epub 2012 May 23. PubMed PMID: 22623647.
  24. Katika MR, Hendriksen PJ, de Ruijter NC, van Loveren H, Peijnenburg A. Immunocytological and biochemical analysis of the mode of action of bis (tri-n-butyltin) tri-oxide (TBTO) in Jurkat cells. Toxicol Lett. 2012 Jul 20;212(2):126-36. doi: 10.1016/j.toxlet.2012.05.010. Epub 2012 May 18. PubMed PMID: 22613032.
  25. Piersma AH, Tonk EC, Makris SL, Crofton KM, Dietert RR, van Loveren H. Juvenile toxicity testing protocols for chemicals. Reprod Toxicol. 2012 Nov;34(3):482-6. doi: 10.1016/j.reprotox.2012.04.010. Epub 2012 May 4. PubMed PMID: 22564981.
  26. Ezendam J, Vermeulen JP, de Klerk A, de Jong WH, van Loveren H. A quantitative approach to assess the potency of skin sensitizers in the elicitation phase. Toxicology. 2012 Sep 4;299(1):20-4. doi: 10.1016/ j.tox.2012.05.002. Epub 2012 May 4. PubMed PMID: 22564262.
  27. Vandebriel RJ, De Jong HJ, Gremmer ER, Klungel OH, Tervaert JW, Slob W, Van Der Laan JW, Van Loveren H. Statins accelerate the onset of collagen type II-induced arthritis in mice. Arthritis Res Ther. 2012 Apr 26;14(2):R90. doi: 10.1186/ar3814. PubMed PMID: 22537858; PubMed Central PMCID: PMC3446464.
  28. van Ravenzwaay B, Brunborg G, Kleinjans J. Conclusions and outlook. Mutat Res. 2012 Aug 15;746(2):171-2. doi:10.1016/j.mrgentox.2012. 04.005. Epub 2012 Apr 16. PubMed PMID: 22531766.
  29. van Ravenzwaay B, Brunborg G, Kleinjans J, Galay Burgos M, Vrijhof H. Use of 'omics to elucidate mechanism of action and integration of 'omics in a systems biology concept. Mutat Res. 2012 Aug 15;746(2):95-6. doi: 10.1016/j.mrgentox.2012.04.004. Epub 2012 Apr 13. PubMed PMID: 22525362.
  30. Doktorova TY, Ellinger-Ziegelbauer H, Vinken M, Vanhaecke T, van Delft J, Kleinjans J, Ahr HJ, Rogiers V. Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver. Arch Toxicol. 2012 Sep;86(9):1399-411. doi: 10.1007/ s00204-012-0847-x. Epub 2012 Apr 8. PubMed PMID: 22484513.
  31. van Kol SW, Hendriksen PJ, van Loveren H, Peijnenburg A. Transcriptomics analysis of primary mouse thymocytes exposed to bis(tri-n-butyltin)dioxide (TBTO). Toxicology. 2012 Jun 14;296(1-3):37-47. doi: 10.1016/j.tox.2012.03.002. Epub 2012 Mar 14. PubMed PMID: 22434021.
  32. Lizarraga D, Gaj S, Brauers KJ, Timmermans L, Kleinjans JC, van Delft JH. Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49. doi: 10.1021/ tx2003799. Epub 2012 Feb 22. PubMed PMID: 22316170.
  33. Tonk EC, Verhoef A, Gremmer ER, van Loveren H, Piersma AH. Relative sensitivity of developmental and immune parameters in juvenile versus adult male rats after exposure to di(2-ethylhexyl) phthalate. Toxicol Appl Pharmacol. 2012 Apr 1;260(1):48-57. doi: 10.1016/j.taap.2012.01.018. Epub 2012 Jan 31. PubMed PMID: 22310177.
  34. Jetten MJ, Gaj S, Ruiz-Aracama A, de Kok TM, van Delft JH, Lommen A, van Someren EP, Jennen DG, Claessen SM, Peijnenburg AA, Stierum RH, Kleinjans JC. 'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):320-8. doi: 10.1016/j.taap.2012.01.009. Epub 2012 Jan 20. PubMed PMID: 22285215.
  35. Sansone SA, Rocca-Serra P, Field D, Maguire E, Taylor C, Hofmann O, Fang H, Neumann S, Tong W, Amaral-Zettler L, Begley K, Booth T, Bougueleret L, Burns G, Chapman B, Clark T, Coleman LA, Copeland J, Das S, de Daruvar A, de Matos P, Dix I, Edmunds S, Evelo CT, Forster MJ, Gaudet P, Gilbert J, Goble C, Griffin JL, Jacob D, Kleinjans J, Harland L, Haug K, Hermjakob H, Ho Sui SJ, Laederach A, Liang S, Marshall S, McGrath A, Merrill E, Reilly D, Roux M, Shamu CE, Shang CA,
  36. Steinbeck C, Trefethen A, Williams-Jones B, Wolstencroft K, Xenarios I, Hide W. Toward interoperable bioscience data. Nat Genet. 2012 Jan 27;44(2):121-6. doi: 10.1038/ng.1054. PubMed PMID: 22281772; PubMed Central PMCID: PMC3428019.
  37. Van Summeren A, Renes J, van Delft JH, Kleinjans JC, Mariman EC. Proteomics in the search for mechanisms and biomarkers of drug-induced hepatotoxicity. Toxicol In Vitro. 2012 Apr;26(3):373-85. doi: 10.1016/j.tiv.2012.01.012. Epub 2012 Jan 17. Review. PubMed PMID: 22274661.
  38. Hochstenbach K, van Leeuwen DM, Gottschalk RW, Gmuender H, Stølevik SB, Nygaard UC, Løvik M, Granum B, Namork E, van Loveren H, van Delft JH. Transcriptomic fingerprints in human peripheral blood mononuclear cells indicative of genotoxic and non-genotoxic carcinogenic exposure. Mutat Res. 2012 Aug 15;746(2):124-34. doi: 10.1016/ j.mrgentox.2012.01.002. Epub 2012 Jan 16. PubMed PMID: 22269147.
  39. Radford R, Slattery C, Jennings P, Blaque O, Pfaller W, Gmuender H, Van Delft J, Ryan MP, McMorrow T. Carcinogens induce loss of the primary cilium in human renal proximal tubular epithelial cells independently of effects on the cell cycle. Am J Physiol Renal Physiol. 2012 Apr 15;302(8): F905-16. doi: 10.1152/ajprenal.00427.2011. Epub 2012 Jan 18. PubMed PMID: 22262483.
  40. van Loveren H, Sanz Y, Salminen S. Health claims in Europe: probiotics and prebiotics as case examples. Annu Rev Food Sci Technol. 2012;3:247-61. doi: 10.1146/annurev-food-022811-101206. Epub 2012 Jan 3. Review. PubMed PMID: 22224554.
  41. Osman AM, van Loveren H. Phosphoproteomic analysis of mouse thymoma cells treated with tributyltin oxide: TBTO affects proliferation and energy sensing pathways. Toxicol Sci. 2012 Mar; 126(1):84-100. doi: 10.1093/ toxsci/kfr333. Epub 2011 Dec 15. PubMed PMID: 22174045.
  42. Theunissen PT, Robinson JF, Pennings JL, de Jong E, Claessen SM, Kleinjans JC, Piersma AH. Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn). Toxicol Sci. 2012 Feb;125(2):430-8. doi: 10.1093/ toxsci/kfr293. Epub 2011 Nov 1. PubMed PMID: 22045034.
  43. Hebels DG, Sveje KM, de Kok MC, van Herwijnen MH, Kuhnle GG, Engels LG, Vleugels-Simon CB, Mares WG, Pierik M, Masclee AA, Kleinjans JC, de Kok TM. Red meat intake-induced increases in fecal water genotoxicity correlate with pro-carcinogenic gene expression changes in the human colon. Food Chem Toxicol. 2012 Feb;50(2):95-103. doi: 10.1016/ j.fct.2011.10.038. Epub 2011 Oct 14. PubMed PMID: 22019696.
  44. Cramers P, Filon AR, Pines A, Kleinjans JC, Mullenders LH, van Zeeland AA. Enhanced nucleotide excision repair in human fibroblasts pre-exposed to ionizing radiation. Photochem Photobiol. 2012 Jan-Feb;88(1):147-53. doi: 10.1111/j.1751-1097.2011.01019.x. Epub 2011 Nov 17. PubMed PMID: 22017241.
  45. de Jong HJ, Klungel OH, van Dijk L, Vandebriel RJ, Leufkens HG, van der Laan JW, Cohen Tervaert JW, van Loveren H. Use of statins is associated with an increased risk of rheumatoid arthritis. Ann Rheum Dis. 2012 May;71(5):648-54. doi: 10.1136/ard.2011.155622. Epub 2011 Oct 6. PubMed PMID: 21979000.
  46. Kok TM, Breda SG, Briedé JJ. Genomics-based identification of molecular mechanisms behind the cancer preventive action of phytochemicals: potential and challenges. Curr Pharm Biotechnol. 2012 Jan;13(1):255-64. Review. PubMed PMID: 21466423.