Department of Toxicogenomics

2013

  1. Osman AM, van Loveren H. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. J Appl Toxicol. 2013 Dec 26. doi: 10.1002/jat.2966. PubMed PMID: 24375594.
  2. Shao J, Berger LF, Hendriksen PJ, Peijnenburg AA, van Loveren H, Volger OL. Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89. doi: 10.1007/ s00204-013-1179-1. Epub 2013 Dec 20. PubMed PMID: 24356939.
  3. De Boever P, Wens B, Forcheh AC, Reynders H, Nelen V, Kleinjans J, Van Larebeke N, Verbeke G, Valkenborg D, Schoeters G. Characterization of the peripheral blood transcriptome in a repeated measures design using a panel of healthy individuals. Genomics. 2014 Jan;103(1):31-9. doi:10.1016/j.ygeno.2013.11.006. Epub 2013 Dec 7. PubMed PMID: 24321174.
  4. Rieswijk L, Lizarraga D, Brauers KJ, Kleinjans JC, van Delft JH. Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks. Mutagenesis. 2014 Jan;29(1): 17-26. doi: 10.1093/mutage/get055. Epub 2013 Nov 26. PubMed PMID: 24280081.
  5. Fijten RR, Jennen DG, van Delft JH. Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Curr Drug Metab. 2013 Dec;14(10):1022-8. PubMed PMID: 24261707.
  6. Merlo DF, Agramunt S, Anna L, Besselink H, Botsivali M, Brady NJ, Ceppi M, Chatzi L, Chen B, Decordier I, Farmer PB, Fleming S, Fontana V, Försti A, Fthenou E, Gallo F, Georgiadis P, Gmuender H, Godschalk RW, Granum B, Hardie LJ, Hemminki K, Hochstenbach K, Knudsen LE, Kogevinas M, Kovács K, Kyrtopoulos SA, Løvik M, Nielsen JK, Nygaard UC, Pedersen M, Rydberg P, Schoket B, Segerbäck D, Singh R, Sunyer J, Törnqvist M, van Loveren H, van Schooten FJ, Vande Loock K, von Stedingk H, Wright J, Kleinjans JC, Kirsch-Volders M, van Delft JH; NewGeneris Consortium. Micronuclei in cord blood lymphocytes and associations with biomarkers of exposure to carcinogens and hormonally active factors, gene polymorphisms, and gene expression: the NewGeneris cohort. Environ Health Perspect. 2014 Feb;122(2):193-200. doi: 10.1289/ehp.1206324. Epub 2013 Nov 18. PubMed PMID: 24252472; PubMed Central PMCID: PMC3914866.
  7. Schmeits PC, Katika MR, Peijnenburg AA, van Loveren H, Hendriksen PJ. DON shares a similar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stress patterns with the ER stress inducer thapsigargin based on comparative gene expression profiling in Jurkat T cells. Toxicol Lett. 2014 Jan 30;224(3):395-406. doi: 10.1016/j.toxlet.2013.11.005. Epub 2013 Nov 15. PubMed PMID: 24247028.
  8. De Jong HJ, Damoiseaux JG, Vandebriel RJ, Souverein PC, Gremmer ER, Wolfs M, Klungel OH, Van Loveren H, Cohen Tervaert JW, Verschuren WM. Statin use and markers of immunity in the Doetinchem cohort study. PLoS One. 2013 Oct 16;8(10):e77587. doi: 10.1371/journal.pone.0077587. eCollection 2013. PubMed PMID: 24147031; PubMed Central PMCID: PMC3797719.
  9. Kleinjans JC. [Health risks of airborne particulate matter in children]. Ned Tijdschr Geneeskd. 2013; 157(42):A6704. Dutch. PubMed PMID: 24128602.
  10. Emter R, van der Veen JW, Adamson G, Ezendam J, van Loveren H, Natsch A. Gene expression changes induced by skin sensitizers in the KeratinoSens™ cell line: Discriminating Nrf2-dependent and Nrf2-independent events. Toxicol In Vitro. 2013 Dec;27(8):2225-32. doi: 10.1016/ j.tiv. 2013. 09.009. Epub 2013 Sep 20. PubMed PMID: 24055896.
  11. Fucic A, Katic J, Fthenou E, Kogevinas M, Plavec D, Koppe J, Batinic D, Chalkiadaki G, Chatzi L, Lasan R, Kleinjans J, Kirsch-Volders M. Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks. Reprod Toxicol. 2013 Dec;42:110-5. doi: 10.1016/j.reprotox.2013.08.004. Epub 2013 Aug 28. PubMed PMID: 23994514.
  12. Gilsing AM, Fransen F, de Kok TM, Goldbohm AR, Schouten LJ, de Bruïne AP, van Engeland M, van den Brandt PA, de Goeij AF, Weijenberg MP. Dietary heme iron and the risk of colorectal cancer with specific mutations in KRAS and APC. Carcinogenesis. 2013 Dec;34(12):2757-66. doi: 10.1093/carcin/ bgt290. Epub 2013 Aug 27. PubMed PMID: 23983135.
  13. Cavill R, Kleinjans J, Briedé JJ. DTW4Omics: comparing patterns in biological time series. PLoS One. 2013 Aug 20;8(8):e71823. doi: 10.1371/journal.pone.0071823. eCollection 2013. PubMed PMID: 23977154; PubMed Central PMCID: PMC3748037.
  14. Caiment F, Tsamou M, Jennen D, Kleinjans J. Assessing compound carcinogenicity in vitro using connectivity mapping. Carcinogenesis. 2014 Jan;35(1):201-7. doi: 10.1093/carcin/bgt278. Epub 2013 Aug 12. PubMed PMID: 23940306.
  15. Albers R, Bourdet-Sicard R, Braun D, Calder PC, Herz U, Lambert C, Lenoir-Wijnkoop I, Méheust A, Ouwehand A, Phothirath P, Sako T, Salminen S, Siemensma A, van Loveren H, Sack U. Monitoring immune modulation by nutrition in the general population: identifying and substantiating effects on human health. Br J Nutr. 2013 Aug;110 Suppl 2:S1-30. doi: 10.1017/S0007114513001505. PubMed PMID: 23902657.
  16. Jetten MJ, Kleinjans JC, Claessen SM, Chesné C, van Delft JH. Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes. Toxicol In Vitro. 2013 Oct;27(7):2031-40. doi: 10.1016/j.tiv.2013.07.010. Epub 2013 Jul 31. PubMed PMID: 23911569.
  17. Pedersen M, Schoket B, Godschalk RW, Wright J, von Stedingk H, Törnqvist M, Sunyer J, Nielsen JK, Merlo DF, Mendez MA, Meltzer HM, Lukács V, Landström A, Kyrtopoulos SA, Kovács K, Knudsen LE, Haugen M, Hardie LJ, Gützkow KB, Fleming S, Fthenou E, Farmer PB, Espinosa A, Chatzi L, Brunborg G, Brady NJ, Botsivali M, Arab K, Anna L, Alexander J, Agramunt S, Kleinjans JC, Segerbäck D, Kogevinas M. Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris). Environ Health Perspect. 2013 Oct;121(10):1200-6. doi: 10.1289/ehp.1206333. Epub 2013 Jul 19. PubMed PMID: 23906905; PubMed Central PMCID: PMC3801201.
  18. De Jong WH, Van Der Ven LT, Sleijffers A, Park MV, Jansen EH, Van Loveren H, Vandebriel RJ. Systemic and immunotoxicity of silver nanoparticles in an intravenous 28 days repeated dose toxicity study in rats. Biomaterials. 2013 Nov;34(33):8333-43. doi: 10.1016/j.biomaterials.2013.06.048. Epub 2013 Jul 22. PubMed PMID: 23886731.
  19. Kienhuis AS, Vitins AP, Pennings JL, Pronk TE, Speksnijder EN, Roodbergen M, van Delft JH, Luijten M, van der Ven LT. Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis. Toxicol Lett. 2013 Aug 29;221(3):225-36. doi: 10.1016/j.toxlet.2013.06.236. Epub 2013 Jul 3. PubMed PMID: 23830897.
  20. Shao J, Katika MR, Schmeits PC, Hendriksen PJ, van Loveren H, Peijnenburg AA, Volger OL. Toxicogenomics-based identification of mechanisms for direct immunotoxicity. Toxicol Sci. 2013 Oct;135(2):328-46. doi: 10.1093/toxsci/kft151. Epub 2013 Jul 3. PubMed PMID: 23824090.
  21. Vettorazzi A, van Delft J, López de Cerain A. A review on ochratoxin A transcriptomic studies. Food Chem Toxicol. 2013 Sep;59:766-83. doi: 10.1016/j.fct.2013.05.043. Epub 2013 Jun 6. PubMed PMID: 23747715.
  22. De Coster S, van Leeuwen DM, Jennen DG, Koppen G, Den Hond E, Nelen V, Schoeters G, Baeyens W, van Delft JH, Kleinjans JC, van Larebeke N. Gender-specific transcriptomic response to environmental exposure in Flemish adults. Environ Mol Mutagen. 2013 Aug;54(7):574-88. doi: 10.1002/em.21774. Epub 2013 May 8. PubMed PMID: 23653218.
  23. Tonk EC, Verhoef A, Gremmer ER, van Loveren H, Piersma AH. Developmental immunotoxicity in male rats after juvenile exposure to ethanol. Toxicology. 2013 Jul 5;309:91-9. doi: 10.1016/j.tox. 2013.04.003. Epub 2013 Apr 25. PubMed PMID: 23623904.
  24. Vandebriel RJ, De Jong HJ, Gremmer ER, Klungel OH, Tervaert JW, Slob W, Van Der Laan JW, Van Loveren H. Response to 'Statins accelerate the onset of collagen type II-induced arthritis in mice'-authors' reply. Arthritis Res Ther. 2013 Mar 8;15(2):403. [Epub ahead of print] PubMed PMID: 23472848; PubMed Central PMCID: PMC3672814.
  25. Ezendam J, Muller A, Hakkert BC, van Loveren H. Evaluation of the performance of the reduced local lymph node assay for skin sensitization testing. Regul Toxicol Pharmacol. 2013 Jun;66(1):66-71. doi: 10.1016/j.yrtph.2013.02.006. Epub 2013 Feb 28. PubMed PMID: 23459101.
  26. Deferme L, Briedé JJ, Claessen SM, Jennen DG, Cavill R, Kleinjans JC. Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34. doi: 10.1016/j.tox.2013.02.001. Epub 2013 Feb 11. PubMed PMID: 23410634.
  27. Doktorova TY, Yildirimman R, Vinken M, Vilardell M, Vanhaecke T, Gmuender H, Bort R, Brolen G, Holmgren G, Li R, Chesne C, van Delft J, Kleinjans J, Castell J, Bjorquist P, Herwig R, Rogiers V. Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models. Carcinogenesis. 2013 Jun;34(6):1393-402. doi: 10.1093/carcin/bgt054. Epub 2013 Feb 7. PubMed PMID: 23393228.
  28. Hebels DG, Georgiadis P, Keun HC, Athersuch TJ, Vineis P, Vermeulen R, Portengen L, Bergdahl IA, Hallmans G, Palli D, Bendinelli B, Krogh V, Tumino R, Sacerdote C, Panico S, Kleinjans JC, de Kok TM, Smith MT, Kyrtopoulos SA; EnviroGenomarkers Project Consortium. Performance in omics analyses of blood samples in long-term storage: opportunities for the exploitation of existing Biobanks in environmental health research. Environ Health Perspect. 2013 Apr;121(4):480-7. doi: 10.1289/ ehp.1205657. Epub 2013 Feb 4. PubMed PMID: 23384616; PubMed Central PMCID: PMC3620742.
  29. Hettne KM, Boorsma A, van Dartel DA, Goeman JJ, de Jong E, Piersma AH, Stierum RH, Kleinjans JC, Kors JA. Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data. BMC Med Genomics. 2013 Jan 29;6:2. doi: 10.1186/1755-8794-6-2. PubMed PMID: 23356878; PubMed Central PMCID: PMC3572439.
  30. Granum B, Haug LS, Namork E, Stølevik SB, Thomsen C, Aaberge IS, van Loveren H, Løvik M, Nygaard UC. Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood. J Immunotoxicol. 2013 Oct-Dec;10(4):373-9. doi: 10.3109/1547691X.2012.755580. Epub 2013 Jan 25. PubMed PMID: 23350954.
  31. Schults MA, Chiu RK, Nagle PW, Wilms LC, Kleinjans JC, van Schooten FJ, Godschalk RW. Genetic polymorphisms in catalase and CYP1B1 determine DNA adduct formation by benzo(a)pyrene ex vivo. Mutagenesis. 2013 Mar;28(2):181-5. doi: 10.1093/mutage/ges070. Epub 2013 Jan 15. PubMed PMID: 23325794.
  32. Van Summeren A, Renes J, Lizarraga D, Bouwman FG, Noben JP, van Delft JH, Kleinjans JC, Mariman EC. Screening for drug-induced hepatotoxicity in primary mouse hepatocytes using acetaminophen, amiodarone, and cyclosporin a as model compounds: an omics-guided approach. OMICS. 2013 Feb;17(2):71-83. doi: 10.1089/omi.2012.0079. Epub 2013 Jan 11. PubMed PMID: 23308384; PubMed Central PMCID: PMC3567623.
  33. Vanhees K, van Schooten FJ, van Waalwijk van Doorn-Khosrovani SB, van Helden S, Munnia A, Peluso M, Briedé JJ, Haenen GR, Godschalk RW. Intrauterine exposure to flavonoids modifies antioxidant status at adulthood and decreases oxidative stress-induced DNA damage. Free Radic Biol Med. 2013 Apr;57:154-61. doi: 10.1016/j.freeradbiomed.2012.12.021. Epub 2013 Jan 4. PubMed PMID: 23295412.
  34. Schmeits PC, Volger OL, Zandvliet ET, van Loveren H, Peijnenburg AA, Hendriksen PJ. Assessment of the usefulness of the murine cytotoxic T cell line CTLL-2 for immunotoxicity screening by transcriptomics. Toxicol Lett. 2013 Feb 13;217(1):1-13. doi: 10.1016/j.toxlet.2012.12.005. Epub 2012 Dec 17. PubMed PMID: 23253260.
  35. Theunissen PT, Pennings JL, van Dartel DA, Robinson JF, Kleinjans JC, Piersma AH. Complementary detection of embryotoxic properties of substances in the neural and cardiac embryonic stem cell tests. Toxicol Sci. 2013 Mar;132(1):118-30. doi: 10.1093/toxsci/kfs333. Epub 2012 Dec 13. PubMed PMID: 23243006.
  36. van der Veen JW, Gremmer ER, Vermeulen JP, van Loveren H, Ezendam J. Induction of skin sensitization is augmented in Nrf2-deficient mice. Arch Toxicol. 2013 Apr;87(4):763-6. doi: 10.1007/s00204-012-0976-2. Epub 2012 Nov 11. PubMed PMID: 23143620.
  37. van Kesteren PC, Zwart PE, Schaap MM, Pronk TE, van Herwijnen MH, Kleinjans JC, Bokkers BG, Godschalk RW, Zeilmaker MJ, van Steeg H, Luijten M. Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: toxicokinetics is essential for in vivo-in vitro comparisons. Arch Toxicol. 2013 Mar;87(3):505-15. doi: 10.1007/s00204-012-0949-5. Epub 2012 Oct 2. PubMed PMID: 23052197.
  38. Stølevik SB, Nygaard UC, Namork E, Haugen M, Meltzer HM, Alexander J, Knutsen HK, Aaberge I, Vainio K, van Loveren H, Løvik M, Granum B. Prenatal exposure to polychlorinated biphenyls and dioxins from the maternal diet may be associated with immunosuppressive effects that persist into early childhood. Food Chem Toxicol. 2013 Jan;51:165-72. doi: 10.1016/j.fct.2012.09.027. Epub 2012 Oct 2. PubMed PMID: 23036451.
  39. Tonk EC, de Groot DM, Wolterbeek AP, Penninks AH, Waalkens-Berendsen ID, Piersma AH, van Loveren H. Developmental immunotoxicity of ethanol in an extended one-generation reproductive toxicity study. Arch Toxicol. 2013 Feb;87(2):323-35. doi: 10.1007/s00204-012-0940-1. Epub 2012 Sep 25. PubMed PMID: 23007559.
  40. van der Veen JW, Pronk TE, van Loveren H, Ezendam J. Applicability of a keratinocyte gene signature to predict skin sensitizing potential. Toxicol In Vitro. 2013 Feb;27(1):314-22. doi: 10.1016/ j.tiv.2012.08.023. Epub 2012 Aug 28. PubMed PMID: 22935770.